<i>GPRC5C</i> | Class C Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

GPRC5C

Target id: 260

Nomenclature: GPRC5C

Family: Class C Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GPRC5C in GtoImmuPdb

Gene and Protein Information
class C G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 441 17q25.1-q25.3 GPRC5C G protein-coupled receptor class C group 5 member C 2
Mouse 7 440 11 E2 Gprc5c G protein-coupled receptor, family C, group 5, member C
Rat 7 441 10q32.2 Gprc5c G protein-coupled receptor, class C, group 5, member C
Previous and Unofficial Names
RAIG3 | retinoic acid-induced gene 3 protein | G protein-coupled receptor, family C, group 5, member C | G protein-coupled receptor, class C, group 5, member C | G protein-coupled receptor
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution
Highest expression in adult cerebellum, spinal cord, liver, lung, kidney, pancreas, spleen, stomach and prostate.
Species:  Human
Technique:  RT-PCR
References:  2
High expression in adult kidney, pancreas and prostate.
Medium expression in adult liver and spleen.
Low expression in colon, small intestine and testis.
Not detectable in brain, heart, lung, placenta, skeletal muscle, ovary, leukocyte and thymus.
Species:  Human
Technique:  RT-PCR
References:  1
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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General Comments
Orphan receptor.
mRNA expression is induced by retinoic acid in some cell lines.

References

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1. Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P. (2001) Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Biochim Biophys Acta., 1518: 237-248. [PMID:11311935]

2. Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN. (2000) Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). Genomics, 67: 8-18. [PMID:10945465]

Contributors

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How to cite this page

Hans Bräuner-Osborne.
Class C Orphans: GPRC5C. Last modified on 15/08/2014. Accessed on 14/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=260.