CD2 | CD molecules | IUPHAR/BPS Guide to PHARMACOLOGY

CD2

Target id: 2600

Nomenclature: CD2

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     CD2 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 351 1p13 CD2 CD2 molecule
Mouse - 344 3 F2.2 Cd2 CD2 antigen
Rat - 344 2q34 Cd2 Cd2 molecule
Database Links
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
alefacept Hs Inhibition - - 1-2
[1-2]
Immunopharmacology Comments
CD2 is a cell surface glycoprotein expressed on most human T cells and natural killer (NK) cells [3] as well as by the majority of T cell lymphomas and leukemias. CD2 functions as a cell adhesion and co-stimulatory molecule. It is known to bind lymphocyte function-associated antigen-3 (LFA-3/CD58), a surface molecule expressed by antigen presenting cells and epithelial cells. The CD2/CD58 interaction promotes the initial stages of cell contact and facilitates T-cell receptor (TCR) triggering. CD2 is used as a specific marker for T cells and NK cells, and to distinguish B cell neoplasms from T cell lymphomas and leukemias.
Cell Type Associations
Immuno Cell Type:  B cells
Immuno Cell Type:  T cells
Immuno Cell Type:  Natural killer cells
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0030887 positive regulation of myeloid dendritic cell activation NAS
GO:0050900 leukocyte migration TAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0042110 T cell activation TAS
GO:0045580 regulation of T cell differentiation NAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0030887 positive regulation of myeloid dendritic cell activation NAS
GO:0045580 regulation of T cell differentiation NAS
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0045580 regulation of T cell differentiation NAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0032760 positive regulation of tumor necrosis factor production IDA
GO:1902715 positive regulation of interferon-gamma secretion IDA
GO:2000484 positive regulation of interleukin-8 secretion IMP
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 2 GO processes
GO:0045580 regulation of T cell differentiation NAS
GO:0050900 leukocyte migration TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0030101 natural killer cell activation NAS
GO:0030887 positive regulation of myeloid dendritic cell activation NAS
GO:0042110 T cell activation TAS
GO:0045580 regulation of T cell differentiation NAS
Immuno Disease Associations
Disease Name:  Psoriasis
Disease Synonyms:  no synonynms
Comment:  CD2 is the molecular target of alefacept, a drug that was approved for the treatment of moderate to severe plaque psoriasis.
Disease X-refs:  Disease Ontology: DOID:8893
References: 

References

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1. da Silva AJ, Brickelmaier M, Majeau GR, Li Z, Su L, Hsu YM, Hochman PS. (2002) Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells. J. Immunol., 168 (9): 4462-71. [PMID:11970990]

2. Mitchell P. (2002) First biotech drug to treat psoriasis. Nat. Biotechnol., 20 (7): 640-1. [PMID:12089534]

3. Yang JJ, Ye Y, Carroll A, Yang W, Lee HW. (2001) Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Curr. Protein Pept. Sci., 2 (1): 1-17. [PMID:12369898]

How to cite this page

CD molecules: CD2. Last modified on 12/07/2018. Accessed on 25/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2600.