fatty acid synthase

Target id: 2608

Nomenclature: fatty acid synthase

Family: 2.3.-.- Acyltransferases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for fatty acid synthase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2511 17q25 FASN fatty acid synthase
Mouse - 2504 11 E2 Fasn fatty acid synthase
Rat - 2505 10 Fasn fatty acid synthase
Previous and Unofficial Names
FAS
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  X-ray structure of human Fatty Acid Synthase Psi/KR Tri-Domain complexed with NADPH and GSK2194069.
PDB Id:  4PIV
Ligand:  GSK2194069
Resolution:  2.3Å
Species:  Human
References:  1
Enzyme Reaction
EC Number: 2.3.1.85

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
GSK2194069 Hs Inhibition 8.1 pIC50 1
pIC50 8.1 (IC50 7.7x10-9 M) [1]

References

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1. Hardwicke MA, Rendina AR, Williams SP, Moore ML, Wang L, Krueger JA, Plant RN, Totoritis RD, Zhang G, Briand J et al.. (2014) A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site. Nat. Chem. Biol.10 (9): 774-9. [PMID:25086508]

How to cite this page

2.3.-.- Acyltransferases: fatty acid synthase. Last modified on 13/08/2015. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2608.