hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

Target id: 2622

Nomenclature: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

Family: 1.-.-.- Oxidoreductases, 5.-.-.- Isomerases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1730 1p12 HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Mouse - 373 3 F2.2 Hsd3b1 hydroxy-delta-5-steroid dehydrogenase
Rat - 373 2q34 Hsd3b1 hydroxy-delta-5-steroid dehydrogenase
Previous and Unofficial Names
3 beta-hydroxysteroid dehydrogenase/Delta 5 | Hsd3b2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | hydroxy-delta-5-steroid dehydrogenase
Database Links
BRENDA
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.1.1.145
EC Number: 5.3.3.1

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Inhibitors
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Ligand Sp. Action Affinity Units Reference
trilostane N/A Inhibition 8.4 pIC50 1
pIC50 8.4 (IC50 4x10-9 M) Note that the species is not specified in the referenced article. [1]
Description: In vitro enzyme inhibition
Clinically-Relevant Mutations and Pathophysiology
Disease:  Congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase type II deficiency
Synonyms: Congenital adrenal hyperplasia [Disease Ontology: DOID:12255]
Disease Ontology: DOID:12255
OMIM: 201810
Orphanet: ORPHA90791

References

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1. Rabe T, Kiesel L, Kellermann J, Weidenhammer K, Runnebaum B, Potts GO. (1983) Inhibition of human placental progesterone synthesis and aromatase activity by synthetic steroidogenic inhibitors in vitro. Fertil. Steril.39 (6): 829-35. [PMID:6574022]

How to cite this page

5.-.-.- Isomerases: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2. Last modified on 13/08/2015. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2622.