CD20 (membrane-spanning 4-domains, subfamily A, member 1)

Target id: 2628

Nomenclature: CD20 (membrane-spanning 4-domains, subfamily A, member 1)

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     CD20 (membrane-spanning 4-domains, subfamily A, member 1) has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 297 11q12-q13.1 MS4A1 membrane spanning 4-domains A1
Mouse 4 291 19 B Ms4a1 membrane-spanning 4-domains, subfamily A, member 1
Rat - 297 1q43 Ms4a1 membrane spanning 4-domains A1
Previous and Unofficial Names
B-lymphocyte antigen CD20 | MS4A2 | membrane-spanning 4-domains, subfamily A, member 1
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
ofatumumab Hs Binding 9.9 pKd 8
pKd 9.9 (Kd 1.21x10-10 M) [8]
Description: Binding affinity for clone 2F2 ((HuMax-CD20).
ocrelizumab Hs Binding 9.1 pKd 1
pKd 9.1 (Kd 8.4x10-10 M) [1]
rituximab Hs Binding 8.5 pKd 11
pKd 8.5 (Kd 3.1x10-9 M) [11]
veltuzumab Hs Binding 8.4 pKd 11
pKd 8.4 (Kd 3.6x10-9 M) [11]
ibritumomab tiuxetan Hs Binding - -
tositumomab Hs Binding - -
obinutuzumab Hs Binding - - 2,10
[2,10]
ublituximab Hs Binding - - 6
[6]
Antibody Comments
Ofatumumab, rituximab, tositumomab and ibritumomab tiuxetan are monoclonal antibodies against the CD20 molecule (MS4A1, membrane-spanning 4-domains, subfamily A, member 1). These references contain some details of their use and function:- [3,7,9,13,15].
Although the KD value for ofatumumab is derived from [8], the originating patent is US8529902 [12].
Immunopharmacology Comments
CD20 is a B cell antigen, involved in B cell development and maturation to antibody-producing plasma cells [4]. CD20 has no known ligand and is suggested to act as a calcium channel. CD20 is the target of monoclonal antibodies approved for the treatment of B cell lymphomas and leukemias (rituximab, obinutuzumab, Ibritumomab tiuxetan, ofatumumab and tositumomab). In obses mice, anti-CD20 antibodies prevent insulin insensitivity and development of diabetes mellitus or metabolic syndrome [14], suggesting a potentially druggable autoimmune link between obesity, diabetes mellitus and metabolic syndrome.
Immuno Cell Type Associations
Immuno Cell Type:  B cells
Cell Ontology Term:   B cell (CL:0000236)
Comment: 
References: 
Immuno Process Associations
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  B cell proliferation (GO:0042100) NAS
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  B cell proliferation (GO:0042100) NAS
References: 
Immuno Disease Associations
Disease Name:  Pemphigus
Disease Synonyms:  no synonynms
Comment:  CD20 is the molecular target of the antibody veltuzumab.
Disease X-refs:  Disease Ontology: DOID:9182
References: 
Disease Name:  Relapsing-remitting multiple sclerosis
Disease Synonyms:  no synonynms
Comment:  CD20 is the molecular target of the RRMS therapeutic ocrelizumab.
Disease X-refs:  Disease Ontology: DOID:2378
References: 
Disease Name:  non-Hodgkin lymphoma
Disease Synonyms:  no synonynms
Comment:  CD20 is the molecular target of the B cell NHL therapeutic ibritumomab tiuxetan.
Disease X-refs:  Disease Ontology: DOID:0060060
OMIM: 605027
References: 
Disease Name:  Chronic lymphocytic leukemia
Disease Synonyms:  no synonynms
Comment:  CD20 is the molecular target of the CLL therapeutics ofatumumab and obinutuzumab.
Disease X-refs:  Disease Ontology: DOID:1040
OMIM: 151400
Orphanet: ORPHA67038
References: 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Immunodeficiency, common variable, 5; CVID5
Synonyms: Common variable immunodeficiency [Orphanet: ORPHA1572] [Disease Ontology: DOID:12177]
Disease Ontology: DOID:12177
OMIM: 613495
Orphanet: ORPHA1572
References:  5

References

Show »

1. Adams CW, Chan AC, Crowley CW, Lowman HB, Nakamura GR, Presta LG. (2004) Immunoglobulin variants and uses thereof. Patent number: WO2004056312. Assignee: Genentech, Inc.. Priority date: 16/12/2002. Publication date: 08/07/2004.

2. Alduaij W, Ivanov A, Honeychurch J, Cheadle EJ, Potluri S, Lim SH, Shimada K, Chan CH, Tutt A, Beers SA et al.. (2011) Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies. Blood117 (17): 4519-29. [PMID:21378274]

3. Anderson DR, Grillo-López A, Varns C, Chambers KS, Hanna N. (1997) Targeted anti-cancer therapy using rituximab, a chimaeric anti-CD20 antibody (IDEC-C2B8) in the treatment of non-Hodgkin's B-cell lymphoma. Biochem. Soc. Trans.25 (2): 705-8. [PMID:9191187]

4. Cragg MS, Walshe CA, Ivanov AO, Glennie MJ. (2005) The biology of CD20 and its potential as a target for mAb therapy. Curr. Dir. Autoimmun.8: 140-74. [PMID:15564720]

5. Kuijpers TW, Bende RJ, Baars PA, Grummels A, Derks IA, Dolman KM, Beaumont T, Tedder TF, van Noesel CJ, Eldering E et al.. (2010) CD20 deficiency in humans results in impaired T cell-independent antibody responses. J. Clin. Invest.120 (1): 214-22. [PMID:20038800]

6. Le Garff-Tavernier M, Decocq J, de Romeuf C, Parizot C, Dutertre CA, Chapiro E, Davi F, Debré P, Prost JF, Teillaud JL et al.. (2011) Analysis of CD16+CD56dim NK cells from CLL patients: evidence supporting a therapeutic strategy with optimized anti-CD20 monoclonal antibodies. Leukemia25 (1): 101-9. [PMID:20975664]

7. Leandro MJ. (2013) B-cell subpopulations in humans and their differential susceptibility to depletion with anti-CD20 monoclonal antibodies. Arthritis Res. Ther.15 Suppl 1: S3. [PMID:23566754]

8. Liu Q. (2013) Fully human antibodies against human cd20. Patent number: WO2013007052. Assignee: Qingfa Liu. Priority date: 13/07/2011. Publication date: 17/01/2013.

9. Mayes S, Brown N, Illidge TM. (2011) New antibody drug treatments for lymphoma. Expert Opin Biol Ther11 (5): 623-40. [PMID:21395497]

10. Reslan L, Dalle S, Herveau S, Perrial E, Dumontet C. (2013) Apoptotic induction by anti-CD20 antibodies in chronic lymphocytic leukemia: comparison of rituximab and obinutuzumab. Leuk. Lymphoma,  [Epub ahead of print]. [PMID:23537278]

11. Stein R, Qu Z, Chen S, Rosario A, Shi V, Hayes M, Horak ID, Hansen HJ, Goldenberg DM. (2004) Characterization of a new humanized anti-CD20 monoclonal antibody, IMMU-106, and Its use in combination with the humanized anti-CD22 antibody, epratuzumab, for the therapy of non-Hodgkin's lymphoma. Clin. Cancer Res.10 (8): 2868-78. [PMID:15102696]

12. Teeling J, Ruuls S, Glennie M, van de Winkel JGJ, Parren P, Petersen J, Baadsgaard O, Huang H. (2013) for promoting proliferation and/or differentiation of B cells involved in cancers and autoimmune disorders; animal models; genetic engineering. Patent number: US8529902. Assignee: Genmab A/S. Priority date: 17/10/2002. Publication date: 10/09/2013.

13. White CA, Berlfein JR, Grillo-López AJ. (2000) Antibody-targeted immunotherapy for treatment of non-Hodgkin's lymphoma. Curr Pharm Biotechnol1 (4): 303-12. [PMID:11467328]

14. Winer DA, Winer S, Shen L, Wadia PP, Yantha J, Paltser G, Tsui H, Wu P, Davidson MG, Alonso MN et al.. (2011) B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat. Med.17 (5): 610-7. [PMID:21499269]

15. Witzig TE, White CA, Wiseman GA, Gordon LI, Emmanouilides C, Raubitschek A, Janakiraman N, Gutheil J, Schilder RJ, Spies S et al.. (1999) Phase I/II trial of IDEC-Y2B8 radioimmunotherapy for treatment of relapsed or refractory CD20(+) B-cell non-Hodgkin's lymphoma. J. Clin. Oncol.17 (12): 3793-803. [PMID:10577851]

How to cite this page

CD molecules: CD20 (membrane-spanning 4-domains, subfamily A, member 1). Last modified on 06/02/2017. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2628.