NPC1 like intracellular cholesterol transporter 1

Target id: 2629

Nomenclature: NPC1 like intracellular cholesterol transporter 1

Family: Patched family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for NPC1 like intracellular cholesterol transporter 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1359 7p13 NPC1L1 NPC1 like intracellular cholesterol transporter 1
Mouse - 1333 11 A1 Npc1l1 NPC1-like 1
Rat - 1331 14 Npc1l1 NPC1 like intracellular cholesterol transporter 1
Previous and Unofficial Names
Niemann-Pick C1-like protein 1 | NPC1-like 1 | NPC1 like 1
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  The structure of the NPC1L1 N-terminal domain in a closed conformation.
PDB Id:  3QNT
Resolution:  2.83Å
Species:  Human
References:  2

Download all structure-activity data for this target as a CSV file

Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ezetimibe Hs Inhibition 6.7 pKd 1
pKd 6.7 (Kd 2.2x10-7 M) [1]
Description: Measure of ezetimibe glucuronide binding to NPC1L1
Clinically-Relevant Mutations and Pathophysiology Comments
Two rare polymorphisms in the NPC1L1 gene are associated with a non-reponse to ezetimibe in hyperlipidemia patients. For more details see the OMIM entry linked to from this target page.

References

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1. Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, Crona JH, Davis Jr HR, Dean DC, Detmers PA et al.. (2005) The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Proc. Natl. Acad. Sci. U.S.A.102 (23): 8132-7. [PMID:15928087]

2. Kwon HJ, Palnitkar M, Deisenhofer J. (2011) The structure of the NPC1L1 N-terminal domain in a closed conformation. PLoS ONE6 (4): e18722. [PMID:21525977]

How to cite this page

Patched family: NPC1 like intracellular cholesterol transporter 1. Last modified on 14/02/2017. Accessed on 20/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2629.