ribonucleotide reductase regulatory subunit M2

Target id: 2631

Nomenclature: ribonucleotide reductase regulatory subunit M2

Family: Nucleoside synthesis and metabolism, 1.17.4.1 Ribonucleoside-diphosphate reductases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ribonucleotide reductase regulatory subunit M2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 449 2p25-p24 RRM2 ribonucleotide reductase regulatory subunit M2
Mouse - 390 12 A1.3 Rrm2 ribonucleotide reductase M2
Rat - 390 6q16 LOC100359539 ribonucleotide reductase M2 polypeptide
Previous and Unofficial Names
ribonucleoside-diphosphate reductase subunit | Rrm2 | ribonucleotide reductase M2
Database Links
BRENDA
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.17.4.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
clofarabine Hs Inhibition 8.3 pIC50 2
pIC50 8.3 (IC50 5x10-9 M) [2]
Description: Inhibition of growth of K562 cells
fludarabine Hs Inhibition 6.0 pIC50 4
pIC50 6.0 (IC50 1x10-6 M) [4]
Description: Inhibition of ADP reduction by ribonucleotide reductase from HeLa cells
hydroxyurea Hs Inhibition 3.8 pIC50 3
pIC50 3.8 (IC50 1.48x10-4 M) [3]
Description: Dissolved in 1% DMSO, in vitro assay using reconstituted RRM1/RRM2 holoenzyme
gemcitabine Hs Inhibition - - 1
[1]
Inhibitor Comments
Please see the Inhibitors table on the More detailed page for RRM1, for information on approved drugs which may act via this protein.

References

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1. Heinemann V, Xu YZ, Chubb S, Sen A, Hertel LW, Grindey GB, Plunkett W. (1990) Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine. Mol. Pharmacol.38 (4): 567-72. [PMID:2233693]

2. Parker WB, Shaddix SC, Chang CH, White EL, Rose LM, Brockman RW, Shortnacy AT, Montgomery JA, Secrist 3rd JA, Bennett Jr LL. (1991) Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Cancer Res.51 (9): 2386-94. [PMID:1707752]

3. Shao J, Zhou B, Zhu L, Bilio AJ, Su L, Yuan YC, Ren S, Lien EJ, Shih J, Yen Y. (2005) Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay. Biochem. Pharmacol.69 (4): 627-34. [PMID:15670581]

4. Tseng WC, Derse D, Cheng YC, Brockman RW, Bennett Jr LL. (1982) In vitro biological activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine and the biochemical actions of its triphosphate on DNA polymerases and ribonucleotide reductase from HeLa cells. Mol. Pharmacol.21 (2): 474-7. [PMID:7048062]

How to cite this page

1.17.4.1 Ribonucleoside-diphosphate reductases: ribonucleotide reductase regulatory subunit M2. Last modified on 29/01/2016. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2631.