lysine demethylase 4E

Target id: 2679

Nomenclature: lysine demethylase 4E

Family: 1.14.11.- Histone demethylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for lysine demethylase 4E in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 506 11q21 KDM4E lysine demethylase 4E
Previous and Unofficial Names
lysine-specific demethylase 4D-like | KDM4DL | JMJD2E | lysine (K)-specific demethylase 4E
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ML324 Hs Inhibition 6.0 pIC50 1
pIC50 6.0 (IC50 9.2x10-7 M) [1]
compound 6a [PMID: 18942826] Hs Inhibition 5.8 pIC50 2
pIC50 5.8 (IC50 1.4x10-6 M) [2]
Description: FDH (formaldehyde dehydrogenase) coupled assay.

References

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1. Rai G, Kawamura A, Tumber A, Liang Y, Vogel JL, Arbuckle JH, Rose NR, Dexheimer TS, Foley TL, King ON et al.. (2010) Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity. Probe Reports from the NIH Molecular Libraries Program, . [PMID:24260783]

2. Rose NR, Ng SS, Mecinović J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ. (2008) Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J. Med. Chem.51 (22): 7053-6. [PMID:18942826]

How to cite this page

1.14.11.- Histone demethylases: lysine demethylase 4E. Last modified on 25/05/2017. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2679.