lysine demethylase 5A

Target id: 2680

Nomenclature: lysine demethylase 5A

Family: 1.14.11.- Histone demethylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for lysine demethylase 5A in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1690 12p13.33 KDM5A lysine demethylase 5A
Mouse - 1690 6 F1 Kdm5a lysine (K)-specific demethylase 5A
Rat - 1690 4q42 Kdm5a lysine demethylase 5A
Previous and Unofficial Names
lysine (K)-specific demethylase 5A
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
PBIT Hs Inhibition 5.2 pIC50 2
pIC50 5.2 (IC50 6x10-6 M) [2]
GSK-J1 Hs Inhibition 5.2 pIC50 1
pIC50 5.2 (IC50 6.8x10-6 M) [1]

References

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1. Heinemann B, Nielsen JM, Hudlebusch HR, Lees MJ, Larsen DV, Boesen T, Labelle M, Gerlach LO, Birk P, Helin K. (2014) Inhibition of demethylases by GSK-J1/J4. Nature514 (7520): E1-2. [PMID:25279926]

2. Sayegh J, Cao J, Zou MR, Morales A, Blair LP, Norcia M, Hoyer D, Tackett AJ, Merkel JS, Yan Q. (2013) Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J. Biol. Chem.288 (13): 9408-17. [PMID:23408432]

How to cite this page

1.14.11.- Histone demethylases: lysine demethylase 5A. Last modified on 30/03/2016. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2680.