lysine demethylase 7A

Target id: 2686

Nomenclature: lysine demethylase 7A

Family: 1.14.11.- Histone demethylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for lysine demethylase 7A in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 941 7q34 KDM7A lysine demethylase 7A
Mouse - 940 6 B1 Kdm7a lysine (K)-specific demethylase 7A
Previous and Unofficial Names
lysine (K)-specific demethylase 7A
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.11.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
daminozide Hs Inhibition 5.7 pIC50 1
pIC50 5.7 (IC50 2.1x10-6 M) [1]
General Comments
KDM7A is a dual-specificity H3K9/H3K27 demethylase.

References

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1. Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T et al.. (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J. Med. Chem.55 (14): 6639-43. [PMID:22724510]

How to cite this page

1.14.11.- Histone demethylases: lysine demethylase 7A. Last modified on 30/03/2016. Accessed on 12/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2686.