bromodomain adjacent to zinc finger domain 2A

Target id: 2721

Nomenclature: bromodomain adjacent to zinc finger domain 2A

Family: Non-enzymatic BRD containing proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for bromodomain adjacent to zinc finger domain 2A in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1905 12q13.3 BAZ2A bromodomain adjacent to zinc finger domain 2A
Mouse - 1887 10 D3 Baz2a bromodomain adjacent to zinc finger domain, 2A
Rat - 1691 7q11 Baz2a bromodomain adjacent to zinc finger domain, 2A
Previous and Unofficial Names
TIP5 | WALp3 | TTF-I interacting peptide 5 | bromodomain adjacent to zinc finger domain, 2A | bromodomain adjacent to zinc finger domain
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
BAZ2-ICR Hs Inhibition 7.0 pKd 1
pKd 7.0 (Kd 1.09x10-7 M) [1]
Description: Isothermal titration calorimetry (ITC) assay
GSK2801 Hs Inhibition 6.6 pKd 2
pKd 6.6 (Kd 2.57x10-7 M) [2]
Description: Isothermal titration calorimetry (ITC) assay

References

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1. Drouin L, McGrath S, Vidler LR, Chaikuad A, Monteiro O, Tallant C, Philpott M, Rogers C, Fedorov O, Liu M et al.. (2015) Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. J. Med. Chem.58 (5): 2553-9. [PMID:25719566]

2. SGC. GSK2801: A Selective Chemical Probe for BAZ2B/A bromodomains. Accessed on 03/03/2015. Modified on 03/03/2015. thesgc.org, http://www.thesgc.org/chemical-probes/GSK2801

How to cite this page

Non-enzymatic BRD containing proteins: bromodomain adjacent to zinc finger domain 2A. Last modified on 29/01/2016. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2721.