SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

Target id: 2740

Nomenclature: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

Family: Non-enzymatic BRD containing proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1679 19p13.3 SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Mouse - 1617 9 A3 Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Rat - 1613 8q13 Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Previous and Unofficial Names
SNF2-BETA | SWI2 | BAF190 | SWI/SNF related
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
PFI-3 Hs Binding 7.1 pKd 1
pKd 7.1 (Kd 8.9x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Coffin-Siris syndrome
Disease Ontology: DOID:1925
OMIM: 135900
Orphanet: ORPHA1465
Disease:  Mental retardation, autosomal dominant 16; MRD16
Synonyms: Autosomal dominant non-syndromic intellectual disability [Disease Ontology: DOID:0060307]
Disease Ontology: DOID:0060307
OMIM: 614609
Disease:  Rhabdoid tumor predisposition syndrome 2
Synonyms: Familial rhabdoid tumor [Orphanet: ORPHA231108]
OMIM: 613325
Orphanet: ORPHA231108

References

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1. Structural Genomics Consortium. PFI-3: Selective chemical probe for SMARCA bromodomains. Accessed on 10/11/2014. Modified on 10/11/2014. http://www.thesgc.org, http://www.thesgc.org/chemical-probes/PFI-3

How to cite this page

Non-enzymatic BRD containing proteins: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. Last modified on 01/04/2015. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2740.