CD86

Target id: 2745

Nomenclature: CD86

Family: Other immune checkpoint proteins, CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     CD86 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 329 3q21 CD86 CD86 molecule
Mouse - 309 16 B5 Cd86 CD86 antigen
Rat - 313 11q22 Cd86 CD86 molecule
Previous and Unofficial Names
CD86 antigen
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
abatacept Hs Inhibition ~7.9 pKd 2-3
pKd ~7.9 (Kd ~1.2x10-8 M) [2-3]
Description: Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept.
belatacept Hs Inhibition - - 1
[1]
Description: IC50= 0.120µg/mL
Immunopharmacology Comments
CD86 (B7-2) is a type I membrane immunoglobulin. It is expressed on antigen-presenting cells and in association with CD80 provides the costimulatory signal necessary for T cell activation and survival. CD86 interacts with CD28 or CTLA-4 on T cells. It is the interaction with CTLA-4 that is targeted by the approved immunosuppresive drugs abatacept and belatacept.
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   macrophage (CL:0000235)
Comment:  CD86 is expressed on antigen-presenting cells.
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
Immuno Cell Type:  B cells
Cell Ontology Term:   B cell (CL:0000236)
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 5 GO processes
GO:0045630 positive regulation of T-helper 2 cell differentiation NAS
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GO:0002309 T cell proliferation involved in immune response IEA
GO:0034138 toll-like receptor 3 signaling pathway IEA
GO:0034341 response to interferon-gamma IEA
GO:0043011 myeloid dendritic cell differentiation IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 6 GO processes
GO:0031295 T cell costimulation TAS
GO:0042110 T cell activation IC
GO:0045630 positive regulation of T-helper 2 cell differentiation NAS
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
GO:0002309 T cell proliferation involved in immune response IEA
GO:0042104 positive regulation of activated T cell proliferation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 5 GO processes
GO:0031295 T cell costimulation TAS
GO:0045630 positive regulation of T-helper 2 cell differentiation NAS
click arrow to show/hide IEA associations
GO:0002668 negative regulation of T cell anergy IEA
GO:0034138 toll-like receptor 3 signaling pathway IEA
GO:0042104 positive regulation of activated T cell proliferation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 3 GO processes
GO:0045630 positive regulation of T-helper 2 cell differentiation NAS
click arrow to show/hide IEA associations
GO:0002668 negative regulation of T cell anergy IEA
GO:0043011 myeloid dendritic cell differentiation IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 6 GO processes
GO:0038111 interleukin-7-mediated signaling pathway TAS
GO:0043017 positive regulation of lymphotoxin A biosynthetic process NAS
GO:0045086 positive regulation of interleukin-2 biosynthetic process NAS
GO:0045404 positive regulation of interleukin-4 biosynthetic process NAS
click arrow to show/hide IEA associations
GO:0034341 response to interferon-gamma IEA
GO:0071345 cellular response to cytokine stimulus IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 3 GO processes
GO:0031295 T cell costimulation TAS
GO:0045630 positive regulation of T-helper 2 cell differentiation NAS
click arrow to show/hide IEA associations
GO:0042104 positive regulation of activated T cell proliferation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 8 GO processes
GO:0031295 T cell costimulation TAS
GO:0042110 T cell activation IC
GO:0045630 positive regulation of T-helper 2 cell differentiation NAS
click arrow to show/hide IEA associations
GO:0002309 T cell proliferation involved in immune response IEA
GO:0034138 toll-like receptor 3 signaling pathway IEA
GO:0042104 positive regulation of activated T cell proliferation IEA
GO:0042113 B cell activation IEA
GO:0043011 myeloid dendritic cell differentiation IEA
Immuno Process:  Barrier integrity
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0001618 virus receptor activity IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
GO:0042113 B cell activation IEA
Immuno Disease Associations
Disease Name:  Rheumatoid arthritis
Disease Synonyms:  no synonynms
Comment:  CD86 is a primary target of the ligand abatacept, which is clinically approved for the treatment of rheumatoid arthritis.
Disease X-refs:  Disease Ontology: DOID:7148
OMIM: 180300
References:  3
Disease Name:  Graft versus host disease
Disease Synonyms:  no synonynms
Comment:  CD86 is a primary target of the approved anti-rejection drug belatacept.

References

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1. Latek R, Fleener C, Lamian V, Kulbokas 3rd E, Davis PM, Suchard SJ, Curran M, Vincenti F, Townsend R. (2009) Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation. Transplantation, 87 (6): 926-33. [PMID:19300198]

2. Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med., 174 (3): 561-9. [PMID:1714933]

3. Vicente Rabaneda EF, Herrero-Beaumont G, Castañeda S. (2013) Update on the use of abatacept for the treatment of rheumatoid arthritis. Expert Rev Clin Immunol, 9 (7): 599-621. [PMID:23899231]

How to cite this page

CD molecules: CD86. Last modified on 03/01/2018. Accessed on 21/08/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2745.