DNA (cytosine-5-)-methyltransferase 3α

Target id: 2750

Nomenclature: DNA (cytosine-5-)-methyltransferase 3α

Family: 2.1.1.- Methyltransferases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for DNA (cytosine-5-)-methyltransferase 3α in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 912 2p23 DNMT3A DNA methyltransferase 3 alpha
Mouse - 908 12 A2-A3 Dnmt3a DNA methyltransferase 3A
Rat - 908 6q14 Dnmt3a DNA methyltransferase 3 alpha
Gene and Protein Information Comments
Human DNMT3A has a shorter isoform of 723 amino acids.
Previous and Unofficial Names
DNA (cytosine-5-)-methyltransferase 3 alpha
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.1.1.37
Inhibitor Comments
Azacitidine and decitabine are likely to be inhibitors of DNMT1 and DNMT3A. We infer primary target designation from reports of drug action in in vitro and in vivo studies despite the paucity of pharmacological affinity data.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Tatton-Brown-Rahman syndrome; TBRS
Synonyms: Tall stature-intellectual disability-facial dysmorphism syndrome [Orphanet: ORPHA404443]
OMIM: 615879
Orphanet: ORPHA404443

How to cite this page

2.1.1.- Methyltransferases: DNA (cytosine-5-)-methyltransferase 3α. Last modified on 13/08/2015. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2750.