peptidylprolyl isomerase A

Target id: 2751

Nomenclature: peptidylprolyl isomerase A

Family: 5.2.-.- Cis-trans-isomerases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for peptidylprolyl isomerase A in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 165 7p13 PPIA peptidylprolyl isomerase A
Mouse - 164 11 A1 Ppia peptidylprolyl isomerase A
Rat - 164 14q21 Ppia peptidylprolyl isomerase A
Previous and Unofficial Names
CYPA | peptidylprolyl isomerase A (cyclophilin A)
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Complex of human peptidyl-prolyl cis-trans isomerase A (PPIA, cyclophilin A) and cyclosporin A
PDB Id:  2X2C
Ligand:  cyclosporin A
Resolution:  2.41Å
Species:  Human
References:  2
Enzyme Reaction
EC Number: 5.2.1.8

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
cyclosporin A Hs Inhibition 8.3 pIC50 1
pIC50 8.3 (IC50 5x10-9 M) Inhibition of the phosphatase activity of calcineurin in Jurkat cells. [1]
Inhibitor Comments
Cyclosporin A does not inhibit calcineurin activity directly. It must be in complex with its immunophilin 'receptor', cyclophilin A (PPIA), before it is able to bind and inhibit calcineurin [3].

References

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1. Fruman DA, Klee CB, Bierer BE, Burakoff SJ. (1992) Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc. Natl. Acad. Sci. U.S.A.89 (9): 3686-90. [PMID:1373887]

2. Lammers M, Neumann H, Chin JW, James LC. (2010) Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. Nat. Chem. Biol.6 (5): 331-7. [PMID:20364129]

3. Liu J, Farmer Jr JD, Lane WS, Friedman J, Weissman I, Schreiber SL. (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell66 (4): 807-15. [PMID:1715244]

How to cite this page

5.2.-.- Cis-trans-isomerases: peptidylprolyl isomerase A. Last modified on 29/01/2016. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2751.