ribonucleotide reductase regulatory TP53 inducible subunit M2B

Target id: 2754

Nomenclature: ribonucleotide reductase regulatory TP53 inducible subunit M2B

Family: 1.17.4.1 Ribonucleoside-diphosphate reductases, Nucleoside synthesis and metabolism

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ribonucleotide reductase regulatory TP53 inducible subunit M2B in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 351 8q23.1 RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B
Mouse - 351 15 B3.1 Rrm2b ribonucleotide reductase M2 B (TP53 inducible)
Rat - 351 7q22 Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B
Previous and Unofficial Names
ribonucleotide reductase M2 B (TP53 inducible)
Database Links
BRENDA
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.17.1.4
Inhibitor Comments
Please see the Inhibitors table on the More detailed page for RRM1, for information on approved drugs which may act via this protein.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Mitochondrial DNA depletion syndrome 8A (encephalomyopathic type with renal tubulopathy); MTDPS8A
Synonyms: Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy [Orphanet: ORPHA255235]
OMIM: 612075
Orphanet: ORPHA255235
Disease:  Mitochondrial neurogastrointestinal encephalomyopathy
Synonyms: Mitochondrial neurogastrointestinal encephalopathy syndrome, RRM2B-related [OMIM: 612075]
OMIM: 612075
Orphanet: ORPHA298
Disease:  Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 5
Synonyms: Autosomal dominant progressive external ophthalmoplegia [Orphanet: ORPHA254892]
OMIM: 613077
Orphanet: ORPHA254892

How to cite this page

1.17.4.1 Ribonucleoside-diphosphate reductases: ribonucleotide reductase regulatory TP53 inducible subunit M2B. Last modified on 17/08/2017. Accessed on 21/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2754.