ribonucleotide reductase regulatory TP53 inducible subunit M2B

Target id: 2754

Nomenclature: ribonucleotide reductase regulatory TP53 inducible subunit M2B

Family: 1.17.4.1 Ribonucleoside-diphosphate reductases, Nucleoside synthesis and metabolism

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ribonucleotide reductase regulatory TP53 inducible subunit M2B in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 351 8q23.1 RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B
Mouse - 351 15 B3.1 Rrm2b ribonucleotide reductase M2 B (TP53 inducible)
Rat - 351 7q22 Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B
Previous and Unofficial Names
ribonucleotide reductase M2 B (TP53 inducible)
Database Links
BRENDA
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.17.1.4
Inhibitor Comments
Please see the Inhibitors table on the More detailed page for RRM1, for information on approved drugs which may act via this protein.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Mitochondrial DNA depletion syndrome 8A (encephalomyopathic type with renal tubulopathy); MTDPS8A
Synonyms: Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy [Orphanet: ORPHA255235]
OMIM: 612075
Orphanet: ORPHA255235
Disease:  Mitochondrial neurogastrointestinal encephalomyopathy
Synonyms: Mitochondrial neurogastrointestinal encephalopathy syndrome, RRM2B-related [OMIM: 612075]
OMIM: 612075
Orphanet: ORPHA298
Disease:  Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 5
Synonyms: Autosomal dominant progressive external ophthalmoplegia [Orphanet: ORPHA254892]
OMIM: 613077
Orphanet: ORPHA254892

How to cite this page

1.17.4.1 Ribonucleoside-diphosphate reductases: ribonucleotide reductase regulatory TP53 inducible subunit M2B. Last modified on 17/08/2017. Accessed on 21/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2754.