neural cell adhesion molecule 1 (CD56)

Target id: 2769

Nomenclature: neural cell adhesion molecule 1 (CD56)

Abbreviated Name: NCAM1

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     neural cell adhesion molecule 1 (CD56) has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 884 11q23.2 NCAM1 neural cell adhesion molecule 1
Mouse 1 1115 9 A5.3 Ncam1 neural cell adhesion molecule 1
Rat 1 858 8q23 Ncam1 neural cell adhesion molecule 1
Gene and Protein Information Comments
Several isoforms of human CD56 have been identified. The longest protein, isoform 5, is listed in the table above. The Entrez gene; 4684 and Uniprot: P13591 records have further details of all of the isoforms currently identified. We also list the longest isoform (3) of the mouse CD56 protein (Entrez Gene, Uniprot P13595).
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
CD56 is expressed by neurons, glia, skeletal muscle and natural killer (NK) cells. The CD56bright NK cell subset, predominantly present in secondary lymphoid tissues, are capable of high levels of cytokine production, are enriched at inflammatory sites [1], and may have immunoregulatory function [2].
Immuno Cell Type Associations
Immuno Cell Type:  Natural killer cells
Cell Ontology Term:   CD16-negative, CD56-bright natural killer cell (CL:0000938)
Comment: 
References: 
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  interferon-gamma-mediated signaling pathway (GO:0060333) TAS
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  interferon-gamma-mediated signaling pathway (GO:0060333) TAS
References: 
Immuno Process:  Barrier integrity
Immuno Process ID:  1
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  virus receptor activity (GO:0001618) IEA
References: 
General Comments
CD56 is used as an immunohistochemical marker for neuroendocrine tumours.

References

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1. Dalbeth N, Gundle R, Davies RJ, Lee YC, McMichael AJ, Callan MF. (2004) CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation. J. Immunol.173 (10): 6418-26. [PMID:15528382]

2. Poli A, Michel T, Thérésine M, Andrès E, Hentges F, Zimmer J. (2009) CD56bright natural killer (NK) cells: an important NK cell subset. Immunology126 (4): 458-65. [PMID:19278419]

How to cite this page

CD molecules: neural cell adhesion molecule 1 (CD56). Last modified on 06/02/2017. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2769.