kinesin-5

Target id: 2788

Nomenclature: kinesin-5

Family: Kinesins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kinesin-5 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1056 10q24.1 KIF11 kinesin family member 11
Mouse - 1052 19 C2 Kif11 kinesin family member 11
Rat - 1056 1q53 Kif11 kinesin family member 11
Previous and Unofficial Names
BimC | Eg5
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
AZD4877 Hs Inhibition 8.7 pIC50 1
pIC50 8.7 (IC50 2x10-9 M) [1]
Description: Measured as inhibition of ATPase activity of a 369 amino acid N-terminal fragment of hKIF11
Clinically-Relevant Mutations and Pathophysiology
Disease:  Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation; MCLMR
Synonyms: Microcephaly - lymphedema - chorioretinopathy [Orphanet: ORPHA2526]
OMIM: 152950
Orphanet: ORPHA2526

References

Show »

1. Theoclitou ME, Aquila B, Block MH, Brassil PJ, Castriotta L, Code E, Collins MP, Davies AM, Deegan T, Ezhuthachan J et al.. (2011) Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. J. Med. Chem.54 (19): 6734-50. [PMID:21899292]

How to cite this page

Kinesins: kinesin-5. Last modified on 30/03/2017. Accessed on 15/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2788.