NLR family apoptosis inhibitory protein

Target id: 2793

Nomenclature: NLR family apoptosis inhibitory protein

Family: Inhibitors of apoptosis (IAP) protein family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for NLR family apoptosis inhibitory protein in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1403 5q13.2 NAIP NLR family apoptosis inhibitory protein
Previous and Unofficial Names
baculoviral IAP repeat-containing 1 | BIRC1 | Birc1a | Birc1b | neuronal apoptosis inhibitory protein | NLRB1 | NLR family, apoptosis inhibitory protein | NLR family, apoptosis inhibitory protein 2 | NLR family, BIR domain containing 1 | psiNAIP
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Physiological Functions Comments
Involved in inflammasome formation, caspase-1 activation and inhibition of apoptosis.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Spinal muscular atrophy, type III; SMA3
Synonyms: Kugelberg-Welander disease
Proximal spinal muscular atrophy type 3 [Orphanet: ORPHA83419]
Spinal muscular atrophy [Disease Ontology: DOID:12377]
Disease Ontology: DOID:12377
OMIM: 253400
Orphanet: ORPHA83419
Disease:  Spinal muscular atrophy, type II; SMA2
Synonyms: Proximal spinal muscular atrophy type 2 [Orphanet: ORPHA83418]
Spinal muscular atrophy [Disease Ontology: DOID:12377]
Disease Ontology: DOID:12377
OMIM: 253550
Orphanet: ORPHA83418
Disease:  Spinal muscular atrophy, type I; SMA1
Synonyms: Proximal spinal muscular atrophy type 1 [Orphanet: ORPHA83330]
Spinal muscular atrophy [Disease Ontology: DOID:12377]
Werdnig-Hoffmann disease
Disease Ontology: DOID:12377
OMIM: 253300
Orphanet: ORPHA83330

How to cite this page

Inhibitors of apoptosis (IAP) protein family: NLR family apoptosis inhibitory protein. Last modified on 06/04/2015. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2793.