NRAS

Target id: 2823

Nomenclature: NRAS

Family: RAS subfamily

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for NRAS in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 189 1p13.2 NRAS NRAS proto-oncogene, GTPase
Mouse - 189 3 F2.2 Nras neuroblastoma ras oncogene
Rat - 189 2q34 Nras NRAS proto-oncogene
Previous and Unofficial Names
N-ras | neuroblastoma ras oncogene | neuroblastoma RAS viral (v-ras) oncogene homolog | neuroblastoma RAS viral oncogene homolog | NRAS proto-oncogene, GTPase
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
lonafarnib Hs Inhibition 8.6 pIC50 1
pIC50 8.6 (IC50 2.8x10-9 M) [1]
Description: Measuring inhibition of farnesylation of NRAS by human farnesyltransferase
Clinically-Relevant Mutations and Pathophysiology
Disease:  Colorectal cancer
Disease Ontology: DOID:9256
OMIM: 114500
Disease:  Juvenile myelomonocytic leukemia; JMML
Disease Ontology: DOID:0050458
OMIM: 607785
Orphanet: ORPHA86834
Disease:  Melanocytic nevus syndrome, congenital; CMNS
Synonyms: Congenital melanocytic nevus [Disease Ontology: DOID:3157]
Large congenital melanocytic nevus [Orphanet: ORPHA626]
Disease Ontology: DOID:3157
OMIM: 137550
Orphanet: ORPHA626
Disease:  Melanosis, neurocutaneous; NCMS
OMIM: 249400
Disease:  Nevus, epidermal
Disease Ontology: DOID:0050532
OMIM: 162900
Disease:  Noonan syndrome 6; NS6
Synonyms: Noonan syndrome [Orphanet: ORPHA648] [Disease Ontology: DOID:3490]
Disease Ontology: DOID:3490
OMIM: 613224
Orphanet: ORPHA648
Disease:  RAS-associated autoimmune leukoproliferative disorder; RALD
OMIM: 614470
Orphanet: ORPHA268114
Disease:  Schimmelpenning-Feuerstein-Mims syndrome; SFM
Synonyms: Linear nevus sebaceus syndrome [Orphanet: ORPHA2612]
OMIM: 163200
Orphanet: ORPHA2612
Disease:  Thyroid carcinoma, follicular; FTC
Synonyms: Differentiated thyroid carcinoma [Orphanet: ORPHA146]
Follicular thyroid carcinoma [Disease Ontology: DOID:3962]
Disease Ontology: DOID:3962
OMIM: 188470
Orphanet: ORPHA146

References

Show »

1. Liu M, Bryant MS, Chen J, Lee S, Yaremko B, Lipari P, Malkowski M, Ferrari E, Nielsen L, Prioli N et al.. (1998) Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res.58 (21): 4947-56. [PMID:9810004]

Contributors

Show »

How to cite this page

Elena Faccenda.
RAS subfamily: NRAS. Last modified on 13/08/2015. Accessed on 20/01/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2823.