WD repeat domain 5

Target id: 2831

Nomenclature: WD repeat domain 5

Family: WD repeat-containing proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for WD repeat domain 5 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 334 9q34 WDR5 WD repeat domain 5
Mouse - 334 2 A3 Wdr5 WD repeat domain 5
Rat - 334 3p12 Wdr5 WD repeat domain 5
Previous and Unofficial Names
CFAP89 | cilia and flagella associated protein 89 | SWD3, Set1c WD40 repeat protein
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human WDR5 in complex with compound OICR-9429.
PDB Id:  4QL1
Ligand:  OICR-9429
Resolution:  1.5Å
Species:  Human
References: 

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Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
OICR-9429 Hs Antagonist 7.6 pKd 1
pKd 7.6 (Kd 2.4x10-8 M) [1]
Description: Binding affinity determined by BIACore analysis.
General Comments
WDR5 is involved in the formation of heterotrimeric or multiprotein complexes eg the histone acetyltransferase complex and the histone methyltransferase complex [3-4]. Members of the WD repeat-containing protein family are involved in many cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR5 is reported to associate with the long non-coding RNA HOTTIP which drives histone H3 lysine 4 trimethylation and gene transcription [2].

References

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1. SGC. OICR-9429 - a chemical probe for WDR5. Accessed on 03/03/2015. Modified on 03/03/2015. thesgc.org, http://www.thesgc.org/node/9204

2. Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, Lajoie BR, Protacio A, Flynn RA, Gupta RA et al.. (2011) A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature472 (7341): 120-4. [PMID:21423168]

3. Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W. (2003) Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev.17 (7): 896-911. [PMID:12670868]

4. Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML. (2004) Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol. Cell. Biol.24 (13): 5639-49. [PMID:15199122]

How to cite this page

WD repeat-containing proteins: WD repeat domain 5. Last modified on 08/09/2015. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2831.