egl-9 family hypoxia inducible factor 2

Target id: 2832

Nomenclature: egl-9 family hypoxia inducible factor 2

Abbreviated Name: PHD1

Family: 1.14.11.29 2-oxoglutarate oxygenases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for egl-9 family hypoxia inducible factor 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 407 19q13.2 EGLN2 egl-9 family hypoxia inducible factor 2
Mouse - 419 7 A3 Egln2 egl-9 family hypoxia-inducible factor 2
Rat - 415 1q21 Egln2 egl-9 family hypoxia-inducible factor 2
Gene and Protein Information Comments
Using alternative methionine initiation codons, two isoforms of human EGLN2 have been reported , generating PHD1p40 (374 amino acids; UniProt identifier Q96KS0-2) and PHD1p43 (407 amino acids; UniProt identifier Q96KS0-1). PHD1p43 is considered the canonocal protein.
Previous and Unofficial Names
HIF prolyl hydroxylase 1 | HIFPH1 | egl-9 family hypoxia-inducible factor 2
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.11.29

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 6ee [PMID: 22364528] Hs Inhibition 9.7 pIC50 1
pIC50 9.7 (IC50 2x10-10 M) [1]

References

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1. Vachal P, Miao S, Pierce JM, Guiadeen D, Colandrea VJ, Wyvratt MJ, Salowe SP, Sonatore LM, Milligan JA, Hajdu R et al.. (2012) 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J. Med. Chem.55 (7): 2945-59. [PMID:22364528]

How to cite this page

1.14.11.29 2-oxoglutarate oxygenases: egl-9 family hypoxia inducible factor 2. Last modified on 17/07/2017. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2832.