egl-9 family hypoxia inducible factor 1

Target id: 2833

Nomenclature: egl-9 family hypoxia inducible factor 1

Abbreviated Name: PHD2

Family: 1.14.11.29 2-oxoglutarate oxygenases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for egl-9 family hypoxia inducible factor 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 426 1q42.1 EGLN1 egl-9 family hypoxia inducible factor 1
Mouse - 400 8 E2 Egln1 egl-9 family hypoxia-inducible factor 1
Rat - 338 19q12 Egln1 egl-9 family hypoxia-inducible factor 1
Previous and Unofficial Names
EGL nine (C.elegans) homolog 1 | HIF prolyl hydroxylase 2 | HIFPH2 | SM-20 | ZMYND6 | egl-9 family hypoxia-inducible factor 1
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.11.29

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 6ee [PMID: 22364528] Hs Inhibition 9.7 pIC50 3
pIC50 9.7 (IC50 2x10-10 M) [3]
IOX2 Hs Inhibition 7.7 pIC50 1
pIC50 7.7 (IC50 2.2x10-8 M) [1]
IOX1 Hs Inhibition 4.5 pIC50 2
pIC50 4.5 (IC50 3.3x10-5 M) [2]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Erythrocytosis, familial, 3; ECYT3
Synonyms: Autosomal dominant secondary polycythemia [Orphanet: ORPHA247511]
OMIM: 609820
Orphanet: ORPHA247511

References

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1. Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A et al.. (2013) Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem. Biol.8 (7): 1488-96. [PMID:23683440]

2. Schiller R, Scozzafava G, Tumber A, Wickens JR, Bush JT, Rai G, Lejeune C, Choi H, Yeh TL, Chan MC et al.. (2014) A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem9 (3): 566-71. [PMID:24504543]

3. Vachal P, Miao S, Pierce JM, Guiadeen D, Colandrea VJ, Wyvratt MJ, Salowe SP, Sonatore LM, Milligan JA, Hajdu R et al.. (2012) 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J. Med. Chem.55 (7): 2945-59. [PMID:22364528]

How to cite this page

1.14.11.29 2-oxoglutarate oxygenases: egl-9 family hypoxia inducible factor 1. Last modified on 17/07/2017. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2833.