complement factor D

Target id: 2842

Nomenclature: complement factor D

Family: 3.4.21.46 Complement factor D

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     complement factor D has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 253 19p13.3 CFD complement factor D
Mouse - 259 10 C1 Cfd complement factor D (adipsin)
Rat - 263 7q11 Cfd complement factor D
Gene and Protein Information Comments
Amino acid counts are for the preproproteins.
Previous and Unofficial Names
complement factor D (adipsin)
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  HUMAN COMPLEMENT FACTOR D IN A P21 CRYSTAL FORM
PDB Id:  1HFD
Resolution:  2.3Å
Species:  Human
References:  3

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
example 373 [WO2012093101] Hs Inhibition 9.0 pIC50 1-2
pIC50 9.0 (IC50 1x10-9 M) [1-2]
Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
lampalizumab Hs Binding 10.7 pKi 4
pKi 10.7 (Ki 2x10-11 M) [4]
Immunopharmacology Comments
A protease component of the alternative complement pathway; responsible for cleaving complement factor B.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  complement activation, alternative pathway (GO:0006957) TAS
neutrophil degranulation (GO:0043312) TAS
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  complement activation (GO:0006956) TAS
complement activation, alternative pathway (GO:0006957) TAS
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  neutrophil degranulation (GO:0043312) TAS
References: 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Complement factor D deficiency; CFDD
Synonyms: Factor D deficiency [OMIM: 613912]
Recurrent Neisseria infections due to factor D deficiency [Orphanet: ORPHA169467]
OMIM: 613912
Orphanet: ORPHA169467

References

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1. Abdel-Magid AF. (2012) Factor D Inhibitors for the Treatment of AMD: Patent Highlight. ACS Med Chem Lett3 (10): 781-2. [PMID:24900375]

2. Altmann E, Hommel U, Lorthiois ELJ, Maibaum JK, Ostermann N, Quancard J, Randl SA, Rogel O, Simic O, Vulpetti A. (2012) Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD). Patent number: WO2012093101. Assignee: Novartis Ag. Priority date: 04/01/2011. Publication date: 12/07/2012.

3. Jing H, Babu YS, Moore D, Kilpatrick JM, Liu XY, Volanakis JE, Narayana SV. (1998) Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity. J. Mol. Biol.282 (5): 1061-81. [PMID:9753554]

4. Loyet KM, Good J, Davancaze T, Sturgeon L, Wang X, Yang J, Le KN, Wong M, Hass PE, Campagne Mv et al.. (2014) Complement inhibition in cynomolgus monkeys by anti-factor d antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration. J. Pharmacol. Exp. Ther.351 (3): 527-37. [PMID:25232192]

How to cite this page

3.4.21.46 Complement factor D: complement factor D. Last modified on 17/02/2017. Accessed on 15/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2842.