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Bcl-2-like 2

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2846

Nomenclature: Bcl-2-like 2

Abbreviated Name: Bcl-w

Family: B-cell lymphoma 2 (Bcl-2) protein family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 193 14q11.2 BCL2L2 BCL2 like 2
Mouse - 193 14 27.98 cM Bcl2l2 BCL2-like 2
Rat - 193 15p13 Bcl2l2 Bcl2-like 2
Previous and Unofficial Names Click here for help
BCL2-like 2
Database Links Click here for help
Alphafold Q92843 (Hs), P70345 (Mm)
ChEMBL Target CHEMBL4677 (Hs)
Ensembl Gene ENSG00000129473 (Hs), ENSMUSG00000089682 (Mm), ENSRNOG00000015732 (Rn)
Entrez Gene 599 (Hs), 12050 (Mm), 60434 (Rn)
Human Protein Atlas ENSG00000129473 (Hs)
KEGG Gene hsa:599 (Hs), mmu:12050 (Mm), rno:60434 (Rn)
OMIM 601931 (Hs)
Pharos Q92843 (Hs)
RefSeq Nucleotide NM_004050 (Hs), NM_007537 (Mm), NM_021850 (Rn)
RefSeq Protein NP_004041 (Hs), NP_031563 (Mm), NP_068622 (Rn)
UniProtKB Q92843 (Hs), P70345 (Mm)
Wikipedia BCL2L2 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ABT-737 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Antagonist >9.0 pKi 1
⤷ pKi >9.0 (Ki <1x10-9 M) [1]
venetoclax Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Antagonist 6.6 pKi 2
⤷ pKi 6.6 (Ki 2.45x10-7 M) [2]
Immunopharmacology Comments
The role of Bcl-2 family members in immunity and disease is reviewed in [5]. Pharmacological inhibition of Bcl-2 family proteins reduces disease severity in several animal models of autoimmunity; see ligand ABT-737 [1].

References

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1. Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A, Martineau D, McClellan WJ, Mitten M, Ng SC et al.. (2007) Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem, 50 (4): 641-62. [PMID:17256834]

2. Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J, Dayton BD, Ding H, Enschede SH, Fairbrother WJ et al.. (2013) ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med, 19 (2): 202-8. [PMID:23291630]

How to cite this page

B-cell lymphoma 2 (Bcl-2) protein family: Bcl-2-like 2. Last modified on 31/01/2017. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2846.