MCL1 apoptosis regulator, BCL2 family member | B-cell lymphoma 2 (Bcl-2) protein family | IUPHAR/BPS Guide to PHARMACOLOGY

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MCL1 apoptosis regulator, BCL2 family member

Target not currently curated in GtoImmuPdb

Target id: 2847

Nomenclature: MCL1 apoptosis regulator, BCL2 family member

Abbreviated Name: Mcl-1

Family: B-cell lymphoma 2 (Bcl-2) protein family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 350 1q21 MCL1 MCL1 apoptosis regulator, BCL2 family member
Mouse - 331 3 F2.1 Mcl1 myeloid cell leukemia sequence 1
Rat - 330 2q34 Mcl1 MCL1
Previous and Unofficial Names
BCL2 family apoptosis regulator | MCL1 | MCL1, BCL2 family apoptosis regulator | myeloid cell leukemia 1
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
venetoclax Hs Antagonist <6.3 pKi 1
pKi <6.3 (Ki >4.44x10-7 M) [1]

References

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1. Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J, Dayton BD, Ding H, Enschede SH, Fairbrother WJ et al.. (2013) ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat. Med., 19 (2): 202-8. [PMID:23291630]

How to cite this page

B-cell lymphoma 2 (Bcl-2) protein family: MCL1 apoptosis regulator, BCL2 family member. Last modified on 27/03/2019. Accessed on 27/05/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2847.