CD79B

Target id: 2852

Nomenclature: CD79B

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     CD79B has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 230 17q23 CD79B CD79b molecule
Mouse 1 228 11 E1 Cd79b CD79B antigen
Rat 1 228 10q32.1 Cd79b CD79b molecule
Gene and Protein Information Comments
The table lists the longest isoform of human CD79B, shorter isoforms are reported.
Previous and Unofficial Names
immunoglobulin-associated beta | IGB | CD79b molecule, immunoglobulin-associated beta | Cd79b molecule, immunoglobulin-associated beta
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
polatuzumab vedotin Hs Binding - - 1
[1]
Antibody Comments
The ADC iladatuzumab vedotin (DCDS0780A) is being developed by Hoffmann-La Roche for potential treatment of B-cell non-Hodgkin's lymphoma. It is being evaluated in Phase 1 clinical trial NCT02453087.
Immunopharmacology Comments
CD79B is a component of the multimeric B cell antigen receptor (along with CD79A and a membrane-bound antibody that acts as the antigen recognition moiety). The CD79A/B component is responsible for signal transduction. The B cell antigen receptor complex is reported to be involved in the pathogenesis of various B cell-derived lymphoid cancers [2-3]. Inhibitors of components of B cell receptor signalling are being pursued as novel therapeutics for lymphoid neoplasms, e.g.polatuzumab vedotin is an investigational antibody-drug conjugate targeting a toxic payload to CD79B +ve cells in various hematological malignancies.
Immuno Cell Type Associations
Immuno Cell Type:  B cells
Cell Ontology Term:  
Comment: 
References: 
Immuno Process Associations
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  adaptive immune response (GO:0002250) IEA
B cell differentiation (GO:0030183) IBA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  B cell receptor signaling pathway (GO:0050853) IBA
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  B cell differentiation (GO:0030183) IBA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  B cell differentiation (GO:0030183) IBA
B cell receptor signaling pathway (GO:0050853) IBA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  adaptive immune response (GO:0002250) IEA
References: 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Agammaglobulinemia 6, Autosomal recessive; AGM6
Synonyms: Agammaglobulinemia [Disease Ontology: DOID:2583]
Autosomal agammaglobulinemia [Orphanet: ORPHA33110]
Disease Ontology: DOID:2583
OMIM: 612692
Orphanet: ORPHA33110

References

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1. Chen Y, Dennis M, Dornan D, Elkins K, Junutula JR, Polson A, Zheng B. (2012) Anti-CD79B antibodies and immunoconjugates and methods of use. Patent number: US8088378 B2. Assignee: Genetech Inc.. Priority date: 16/07/2007. Publication date: 03/01/2012.

2. Mraz M, Kipps TJ. (2013) MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia. Leuk. Lymphoma54 (8): 1836-9. [PMID:23597135]

3. Seda V, Mraz M. (2015) B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells. Eur. J. Haematol.94 (3): 193-205. [PMID:25080849]

How to cite this page

CD molecules: CD79B. Last modified on 01/08/2017. Accessed on 21/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2852.