lysyl oxidase like 2

Target id: 2853

Nomenclature: lysyl oxidase like 2

Family: 1.4.3.13 Lysyl oxidases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for lysyl oxidase like 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 774 8p21.3 LOXL2 lysyl oxidase like 2
Mouse - 776 14 D2 Loxl2 lysyl oxidase-like 2
Rat - 776 15p11 Loxl2 lysyl oxidase-like 2
Previous and Unofficial Names
LOR2 | WS9-14 | protein-lysine 6-oxidase | lysyl oxidase homolog 2 | lysyl oxidase-like 2
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.4.3.13
Description Reaction Reference
Reaction is required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices. peptidyl-L-lysyl-peptide + O2 + H2O = peptidyl-allysyl-peptide + NH3 + H2O2 1

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Inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
simtuzumab Hs Inhibition 7.2 pKi 2
pKi 7.2 (Ki 6.7x10-8 M) [2]

References

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1. Harris ED, Gonnerman WA, Savage JE, O'Dell BL. (1974) Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta. Biochim. Biophys. Acta341 (2): 332-44. [PMID:4838158]

2. Smith V, Ogg S, Van Vlasselaer P, Barry VE, Marshall D, Holzer AK, Rodriguez H, Oyasu M, McCauley SA, Garcia CA et al.. (2013) LOX and LOXL2 inhibitors and uses thereof. Patent number: US8461303 B2. Assignee: Gilead Biologics, Inc.. Priority date: 02/08/2007. Publication date: 11/06/2013.

How to cite this page

1.4.3.13 Lysyl oxidases: lysyl oxidase like 2. Last modified on 29/01/2016. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2853.