notch 2

Target id: 2859

Nomenclature: notch 2

Family: Notch receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for notch 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 2471 1p13-p11 NOTCH2 notch 2
Mouse 1 2473 3 F2.2 Notch2 notch 2
Rat 1 2471 2q34 Notch2 notch 2
Previous and Unofficial Names
"Notch homolog 2 (Drosophila)
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

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Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
tarextumab Hs Binding >10.0 pKd 1
pKd >10.0 (Kd <1x10-10 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Alagille syndrome 2; ALGS2
Synonyms: Alagille syndrome [Disease Ontology: DOID:9245]
Alagille syndrome due to a NOTCH2 point mutation [Orphanet: ORPHA261629]
Disease Ontology: DOID:9245
OMIM: 610205
Orphanet: ORPHA261629
Disease:  Hajdu-Cheney syndrome; HJCYS
Synonyms: Acroosteolysis dominant type [Orphanet: ORPHA955]
Disease Ontology: DOID:2736
OMIM: 102500
Orphanet: ORPHA955


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1. Gurney AL, Hoey TC, van der Horst ETH, Sato AK, Liu YC, Bruhns MF, Lewicki JA. (2012) Antibodies to notch receptors. Patent number: US8226943 B2. Assignee: Oncomed Pharmaceuticals, Inc.. Priority date: 08/07/2008. Publication date: 24/07/2012.

How to cite this page

Notch receptors: notch 2. Last modified on 08/05/2017. Accessed on 16/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY,