poly (ADP-ribose) polymerase 3

Target id: 2864

Nomenclature: poly (ADP-ribose) polymerase 3

Abbreviated Name: PARP3

Family: 2.4.2.30 poly(ADP-ribose)polymerases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for poly (ADP-ribose) polymerase 3 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 533 3p21.2 PARP3 poly(ADP-ribose) polymerase family member 3
Mouse - 528 9 F1 Parp3 poly (ADP-ribose) polymerase family
Rat - 526 8q32 Parp3 poly (ADP-ribose) polymerase family
Previous and Unofficial Names
ADPRTL3 | ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3 | IRT1 | pADPRT-3 | poly(ADP-ribose) synthetase-3 | poly (ADP-ribose) polymerase family, member 3 | poly (ADP-ribose) polymerase family
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ME0328 Hs Inhibition 6.1 pIC50 1
pIC50 6.1 (IC50 9x10-7 M) [1]

References

Show »

1. Lindgren AE, Karlberg T, Ekblad T, Spjut S, Thorsell AG, Andersson CD, Nhan TT, Hellsten V, Weigelt J, Linusson A et al.. (2013) Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. J. Med. Chem.56 (23): 9556-68. [PMID:24188023]

How to cite this page

2.4.2.30 poly(ADP-ribose)polymerases: poly (ADP-ribose) polymerase 3. Last modified on 29/01/2016. Accessed on 17/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2864.