kallikrein related peptidase 14

Target id: 2866

Nomenclature: kallikrein related peptidase 14

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kallikrein related peptidase 14 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 267 19q13.3-q13.4 KLK14 kallikrein related peptidase 14
Mouse - 250 7 B4 Klk14 kallikrein related-peptidase 14
Rat - - 1q22 Klk14 kallikrein related-peptidase 14
Previous and Unofficial Names
kallikrein-related peptidase 14
Database Links
Specialist databases
MEROPS S01.029 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 3 [PMID: 23849879] Hs Inhibition 5.9 pIC50 1
pIC50 5.9 (IC50 1.29x10-6 M) [1]
compound 4d [PMID: 25489658] Hs Inhibition 5.5 pIC50 2
pIC50 5.5 (IC50 2.9x10-6 M) [2]

References

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1. Tan X, Furio L, Reboud-Ravaux M, Villoutreix BO, Hovnanian A, El Amri C. (2013) 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg. Med. Chem. Lett.23 (16): 4547-51. [PMID:23849879]

2. Tan X, Soualmia F, Furio L, Renard JF, Kempen I, Qin L, Pagano M, Pirotte B, El Amri C, Hovnanian A et al.. (2015) Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J. Med. Chem.58 (2): 598-612. [PMID:25489658]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 14. Last modified on 29/01/2016. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2866.