peptidyl arginine deiminase 3

Target id: 2878

Nomenclature: peptidyl arginine deiminase 3

Family: 3.5.3.15 Peptidyl arginine deiminases (PADI)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for peptidyl arginine deiminase 3 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 664 1p36.13 PADI3 peptidyl arginine deiminase 3 3
Mouse - 664 4 E1 Padi3 peptidyl arginine deiminase
Rat - 664 5q36 Padi3 peptidyl arginine deiminase 3
Previous and Unofficial Names
PDI3 | peptidyl arginine deiminase, type III | peptidyl arginine deiminase
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.5.3.15 protein L-arginine + H2O <=> protein L-citrulline + NH3

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
streptonigrin N/A Inhibition 6.4 pIC50
pIC50 6.4 (IC50 4.3x10-7 M)
compound 3 [PMID: 24440480] N/A Irreversible inhibition - - 1
[1]
Description: Kinact/KI = 1.8x103 M-1 min-1
compound 14b [PMID: 25742366] Hs Irreversible inhibition - - 2
[2]
Description: Kinact/KI = 1.56x104 M-1 min-1
Cl-amidine Hs Inhibition - - 2
[2]
Description: Kinact/KI = 2.34x103 M-1 min-1
View species-specific inhibitor tables
Tissue Distribution
In human scalp skin the protein is detected in the inner root sheath and outer root sheath of hair follicles, particularly in the supramatrix and keratogenous zone. Protein is almost absent from the cornified hair zone.
Species:  Human
Technique:  Immunohistochemistry.
References:  3
Physiological Functions
Acts as a modulator of hair structural proteins, including trichohyalin during hair and hair follicle formation.
Species:  Human
Tissue:  Human scalp skin.
References:  3

References

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1. Dreyton CJ, Anderson ED, Subramanian V, Boger DL, Thompson PR. (2014) Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorg. Med. Chem.22 (4): 1362-9. [PMID:24440480]

2. Jamali H, Khan HA, Stringer JR, Chowdhury S, Ellman JA. (2015) Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method. J. Am. Chem. Soc.137 (10): 3616-21. [PMID:25742366]

3. Kanno T, Kawada A, Yamanouchi J, Yosida-Noro C, Yoshiki A, Shiraiwa M, Kusakabe M, Manabe M, Tezuka T, Takahara H. (2000) Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin. J. Invest. Dermatol.115 (5): 813-23. [PMID:11069618]

How to cite this page

3.5.3.15 Peptidyl arginine deiminases (PADI): peptidyl arginine deiminase 3. Last modified on 21/03/2017. Accessed on 15/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2878.