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Target not currently curated in GtoImmuPdb
Target id: 2882
Nomenclature: leucine rich repeat and Ig domain containing 1
Abbreviated Name: LINGO1
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 620 | 15q24.3 | LINGO1 | leucine rich repeat and Ig domain containing 1 | |
| Mouse | 1 | 614 | 9 B | Lingo1 | leucine rich repeat and Ig domain containing 1 | |
| Rat | 1 | 620 | 8q24 | Lingo1 | leucine rich repeat and Ig domain containing 1 | |
| Gene and Protein Information Comments | ||||||
| The table above shows details of the longest variant (variant 1) of isoform a of the human LINGO1 protein. Many other shorter variants are described (variants of isoform b). | ||||||
| Previous and Unofficial Names |
| LERN1 | LINGO-1 |
| Database Links |
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| Alphafold | Q96FE5 (Hs), Q9D1T0 (Mm) |
| CATH/Gene3D | 2.60.40.10, 3.80.10.10 |
| ChEMBL Target | CHEMBL3712965 (Hs) |
| Ensembl Gene | ENSG00000169783 (Hs), ENSMUSG00000049556 (Mm), ENSRNOG00000017193 (Rn) |
| Entrez Gene | 84894 (Hs), 235402 (Mm), 315691 (Rn) |
| Human Protein Atlas | ENSG00000169783 (Hs) |
| KEGG Gene | hsa:84894 (Hs), mmu:235402 (Mm), rno:315691 (Rn) |
| OMIM | 609791 (Hs) |
| Pharos | Q96FE5 (Hs) |
| RefSeq Nucleotide | NM_032808 (Hs), NM_001311076 (Mm), NM_001100722 (Rn) |
| RefSeq Protein | NP_116197 (Hs), NP_001298005 (Mm), NP_001094192 (Rn) |
| UniProtKB | Q96FE5 (Hs), Q9D1T0 (Mm) |
| Wikipedia | LINGO1 (Hs) |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| General Comments |
| LINGO1 is a large membrane associated protein which is important for the function of the nervous system. It is an essential negative regulator of myelination, and is implicated in the inhibition of axon regeneration [1-2,4]. Interactions with a variety of different co-factors and co-receptors facilitates LINGO1 effects on the regulation of biological processes involved in neuronal survival, axon regeneration, oligodendrocyte differentiation, or myelination processes in the CNS. |
1. Andrews JL, Fernandez-Enright F. (2015) A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders. Neurosci Biobehav Rev, 56: 97-114. [PMID:26143511]
2. Jepson S, Vought B, Gross CH, Gan L, Austen D, Frantz JD, Zwahlen J, Lowe D, Markland W, Krauss R. (2012) LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions. J Biol Chem, 287 (26): 22184-95. [PMID:22514275]
3. Mi S, Pepinsky B, Graff C. (2011) Composition comprising antibodies to LINGO or fragments thereof. Patent number: US8058406 B2. Assignee: Biogen Idec Ma Inc.. Priority date: 09/11/2016. Publication date: 15/11/2011.
4. Mosyak L, Wood A, Dwyer B, Buddha M, Johnson M, Aulabaugh A, Zhong X, Presman E, Benard S, Kelleher K et al.. (2006) The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition. J Biol Chem, 281 (47): 36378-90. [PMID:17005555]
Reticulons and associated proteins: leucine rich repeat and Ig domain containing 1. Last modified on 23/11/2015. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2882.
