leucine rich repeat and Ig domain containing 1

Target id: 2882

Nomenclature: leucine rich repeat and Ig domain containing 1

Abbreviated Name: LINGO1

Family: Reticulons and associated proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for leucine rich repeat and Ig domain containing 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 620 15q24 LINGO1 leucine rich repeat and Ig domain containing 1
Mouse 1 620 9 A3 Lingo1 leucine rich repeat and Ig domain containing 1
Rat 1 620 8q24 Lingo1 leucine rich repeat and Ig domain containing 1
Gene and Protein Information Comments
The table above shows details of the longest variant (variant 1) of isoform a of the human LINGO1 protein. Many other shorter variants are described (variants of isoform b).
Previous and Unofficial Names
LERN1 | LINGO-1
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
opicinumab Hs Binding >10.0 pEC50 3
pEC50 >10.0 (EC50 <1.1x10-10 M) [3]
Description: Binding to LINGO1 by Fab of the antibody.
General Comments
LINGO1 is a large membrane associated protein which is important for the function of the nervous system. It is an essential negative regulator of myelination, and is implicated in the inhibition of axon regeneration [1-2,4]. Interactions with a variety of different co-factors and co-receptors facilitates LINGO1 effects on the regulation of biological processes involved in neuronal survival, axon regeneration, oligodendrocyte differentiation, or myelination processes in the CNS.

References

Show »

1. Andrews JL, Fernandez-Enright F. (2015) A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders. Neurosci Biobehav Rev56: 97-114. [PMID:26143511]

2. Jepson S, Vought B, Gross CH, Gan L, Austen D, Frantz JD, Zwahlen J, Lowe D, Markland W, Krauss R. (2012) LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions. J. Biol. Chem.287 (26): 22184-95. [PMID:22514275]

3. Mi S, Pepinsky B, Graff C. (2011) Composition comprising antibodies to LINGO or fragments thereof. Patent number: US8058406 B2. Assignee: Biogen Idec Ma Inc.. Priority date: 09/11/2016. Publication date: 15/11/2011.

4. Mosyak L, Wood A, Dwyer B, Buddha M, Johnson M, Aulabaugh A, Zhong X, Presman E, Benard S, Kelleher K et al.. (2006) The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition. J. Biol. Chem.281 (47): 36378-90. [PMID:17005555]

How to cite this page

Reticulons and associated proteins: leucine rich repeat and Ig domain containing 1. Last modified on 23/11/2015. Accessed on 18/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2882.