lymphocyte antigen 96

Target id: 2890

Nomenclature: lymphocyte antigen 96

Abbreviated Name: MD-2

Family: Lymphocyte antigens

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     lymphocyte antigen 96 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 160 8q13.3 LY96 lymphocyte antigen 96
Mouse - 160 1 A3 Ly96 lymphocyte antigen 96
Rat - 160 5 Ly96 lymphocyte antigen 96
Previous and Unofficial Names
LPS co-receptor MD-2 | myeloid differentiation factor-2 | ESOP-1
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
L6H21 Hs Inhibition 4.5 pKd 2
pKd 4.5 (Kd 3.3x10-5 M) [2]
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
neoceptin-3 Hs Binding - - 3
[3]
Immunopharmacology Comments
LY96 (MD2) is a binding partner of Toll-like receptor 4 (TLR4), required to initiate an innate immune response to bacterial lipopolysaccharide (LPS). The signaling complex also contains CD14 co-receptor [1]. LY96 is an important therapeutic target for inflammatory disorders.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  lipopolysaccharide receptor activity (GO:0001875) IDA
toll-like receptor signaling pathway (GO:0002224) TAS
MyD88-dependent toll-like receptor signaling pathway (GO:0002755) TAS
MyD88-independent toll-like receptor signaling pathway (GO:0002756) TAS
inflammatory response (GO:0006954) IEA
negative regulation of MyD88-independent toll-like receptor signaling pathway (GO:0034128) TAS
toll-like receptor 4 signaling pathway (GO:0034142) ISS
TRIF-dependent toll-like receptor signaling pathway (GO:0035666) TAS
innate immune response (GO:0045087) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  lipopolysaccharide receptor activity (GO:0001875) IDA
toll-like receptor signaling pathway (GO:0002224) TAS
MyD88-dependent toll-like receptor signaling pathway (GO:0002755) TAS
MyD88-independent toll-like receptor signaling pathway (GO:0002756) TAS
negative regulation of MyD88-independent toll-like receptor signaling pathway (GO:0034128) TAS
toll-like receptor 4 signaling pathway (GO:0034142) ISS
TRIF-dependent toll-like receptor signaling pathway (GO:0035666) TAS
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of tumor necrosis factor production (GO:0032760) ISS
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  lipopolysaccharide receptor activity (GO:0001875) IDA
toll-like receptor signaling pathway (GO:0002224) TAS
MyD88-dependent toll-like receptor signaling pathway (GO:0002755) TAS
MyD88-independent toll-like receptor signaling pathway (GO:0002756) TAS
negative regulation of MyD88-independent toll-like receptor signaling pathway (GO:0034128) TAS
toll-like receptor 4 signaling pathway (GO:0034142) ISS
TRIF-dependent toll-like receptor signaling pathway (GO:0035666) TAS
References: 
General Comments
ChEMBL target CHEMBL3038513 is the complex of human LY96 and Toll-like receptor 4 (TLR4).

References

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1. Kitchens RL. (2000) Role of CD14 in cellular recognition of bacterial lipopolysaccharides. Chem. Immunol.74: 61-82. [PMID:10608082]

2. Wang Y, Shan X, Chen G, Jiang L, Wang Z, Fang Q, Liu X, Wang J, Zhang Y, Wu W et al.. (2015) MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis. Br. J. Pharmacol.172 (17): 4391-405. [PMID:26076332]

3. Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MM, Huang H, Shi H, Choi JH, Wang KW et al.. (2016) TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proc. Natl. Acad. Sci. U.S.A.113 (7): E884-93. [PMID:26831104]

How to cite this page

Lymphocyte antigens: lymphocyte antigen 96. Last modified on 30/05/2017. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2890.