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peptidyl arginine deiminase 1

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2894

Nomenclature: peptidyl arginine deiminase 1

Family: 3.5.3.15 Peptidyl arginine deiminases (PADI)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 663 1p36.13 PADI1 peptidyl arginine deiminase 1
Mouse - 662 4 72.62 cM Padi1 peptidyl arginine deiminase, type I
Rat - 662 5q36 Padi1 peptidyl arginine deiminase 1
Previous and Unofficial Names Click here for help
HPAD10 | PDI1 | PDI | PAD1 | peptidyl arginine deiminase, type I | peptidyl arginine deiminase
Database Links Click here for help
Alphafold Q9ULC6 (Hs), Q9Z185 (Mm), O88806 (Rn)
BRENDA 3.5.3.15
CATH/Gene3D 2.60.40.1700
ChEMBL Target CHEMBL1909486 (Hs)
Ensembl Gene ENSG00000142623 (Hs), ENSMUSG00000025329 (Mm), ENSRNOG00000007067 (Rn)
Entrez Gene 29943 (Hs), 18599 (Mm), 54282 (Rn)
Human Protein Atlas ENSG00000142623 (Hs)
KEGG Enzyme 3.5.3.15
KEGG Gene hsa:29943 (Hs), mmu:18599 (Mm), rno:54282 (Rn)
OMIM 607934 (Hs)
Pharos Q9ULC6 (Hs)
RefSeq Nucleotide NM_013358 (Hs), NM_011059 (Mm), NM_019332 (Rn)
RefSeq Protein NP_037490 (Hs), NP_035189 (Mm), NP_062205 (Rn)
UniProtKB Q9ULC6 (Hs), Q9Z185 (Mm), O88806 (Rn)
Wikipedia PADI1 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.5.3.15 protein L-arginine + H2O <=> protein L-citrulline + NH3
Description Reaction Reference
protein L-arginine + H2O <=> protein L-citrulline + NH3

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
o-F-amidine Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Irreversible inhibition 5.8 pIC50 1
⤷ pIC50 5.8 (IC50 1.4x10-6 M) [1]

References

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1. Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y et al.. (2011) The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. J Med Chem, 54 (19): 6919-35. [PMID:21882827]

How to cite this page

3.5.3.15 Peptidyl arginine deiminases (PADI): peptidyl arginine deiminase 1. Last modified on 17/10/2018. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2894.