peptidyl arginine deiminase 1

Target id: 2894

Nomenclature: peptidyl arginine deiminase 1

Family: 3.5.3.15 Peptidyl arginine deiminases (PADI)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for peptidyl arginine deiminase 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 663 1p36.13 PADI1 peptidyl arginine deiminase 1
Mouse - 662 4 E1 Padi1 peptidyl arginine deiminase, type I
Rat - 662 5q36 Padi1 peptidyl arginine deiminase 1
Previous and Unofficial Names
HPAD10 | PDI1 | PDI | PAD1 | peptidyl arginine deiminase, type I
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.5.3.15 protein L-arginine + H2O <=> protein L-citrulline + NH3
Description Reaction Reference
protein L-arginine + H2O <=> protein L-citrulline + NH3

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
o-F-amidine Hs Irreversible inhibition 5.8 pIC50 1
pIC50 5.8 (IC50 1.4x10-6 M) [1]

References

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1. Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y et al.. (2011) The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. J. Med. Chem.54 (19): 6919-35. [PMID:21882827]

How to cite this page

3.5.3.15 Peptidyl arginine deiminases (PADI): peptidyl arginine deiminase 1. Last modified on 20/03/2017. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2894.