heat shock protein 90 alpha family class A member 1

Target id: 2905

Nomenclature: heat shock protein 90 alpha family class A member 1

Abbreviated Name: HSP90AA1

Family: Heat shock proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for heat shock protein 90 alpha family class A member 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 732 14q32.33 HSP90AA1 heat shock protein 90 alpha family class A member 1
Mouse - 733 Chromosome 12, 60.75 cM Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1
Rat - 733 6q32 Hsp90aa1 heat shock protein 90 alpha family class A member 1
Previous and Unofficial Names
HSP90AA1
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
BIIB021 Hs Inhibition 8.7 pIC50 1
pIC50 8.7 (IC50 2x10-9 M) [1]
SNX0723 Hs Inhibition 8.5 pIC50 1
pIC50 8.5 (IC50 3x10-9 M) [1]

References

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1. Ernst JT, Liu M, Zuccola H, Neubert T, Beaumont K, Turnbull A, Kallel A, Vought B, Stamos D. (2014) Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases. Bioorg. Med. Chem. Lett.24 (1): 204-8. [PMID:24332488]

How to cite this page

Heat shock proteins: heat shock protein 90 alpha family class A member 1. Last modified on 08/05/2017. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2905.