heat shock protein 90 alpha family class A member 1

Target id: 2905

Nomenclature: heat shock protein 90 alpha family class A member 1

Abbreviated Name: HSP90AA1

Family: Heat shock proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for heat shock protein 90 alpha family class A member 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 732 14q32.33 HSP90AA1 heat shock protein 90 alpha family class A member 1
Mouse - 733 Chromosome 12, 60.75 cM Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1
Rat - 733 6q32 Hsp90aa1 heat shock protein 90 alpha family class A member 1
Previous and Unofficial Names
HSP90AA1
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
retaspimycin hydrochloride Hs Inhibition 6.9 pEC50 2
pEC50 6.9 (EC50 1.19x10-7 M) [2]
BIIB021 Hs Inhibition 8.7 pIC50 1
pIC50 8.7 (IC50 2x10-9 M) [1]
SNX0723 Hs Inhibition 8.5 pIC50 1
pIC50 8.5 (IC50 3x10-9 M) [1]
alvespimycin Hs Inhibition 8.4 pIC50 3
pIC50 8.4 (IC50 4.5x10-9 M) [3]

References

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1. Ernst JT, Liu M, Zuccola H, Neubert T, Beaumont K, Turnbull A, Kallel A, Vought B, Stamos D. (2014) Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases. Bioorg. Med. Chem. Lett.24 (1): 204-8. [PMID:24332488]

2. Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J et al.. (2006) Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J. Med. Chem.49 (15): 4606-15. [PMID:16854066]

3. Kung PP, Funk L, Meng J, Collins M, Zhou JZ, Johnson MC, Ekker A, Wang J, Mehta P, Yin MJ et al.. (2008) Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone. Bioorg. Med. Chem. Lett.18 (23): 6273-8. [PMID:18929486]

How to cite this page

Heat shock proteins: heat shock protein 90 alpha family class A member 1. Last modified on 04/03/2018. Accessed on 19/04/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2905.