heat shock protein 90 alpha family class B member 1

Target id: 2907

Nomenclature: heat shock protein 90 alpha family class B member 1

Abbreviated Name: HSP90AB1

Family: Heat shock proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     heat shock protein 90 alpha family class B member 1 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 724 6p21.1 HSP90AB1 heat shock protein 90 alpha family class B member 1
Mouse - 724 Chromosome 17, 22.59 cM Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1
Rat - 724 9q12 Hsp90ab1 heat shock protein 90 alpha family class B member 1
Previous and Unofficial Names
HSP90AB1 | HSp90AB1 | heat shock protein 90 alpha (cytosolic), class B member 1 | heat shock protein 90 alpha (cytosolic)
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
luminespib Hs Inhibition 8.7 pIC50
pIC50 8.7 (IC50 2x10-9 M)
geldanamycin Hs Inhibition 6.6 pIC50 1
pIC50 6.6 (IC50 2.82x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0043312 neutrophil degranulation TAS
GO:0060334 regulation of interferon-gamma-mediated signaling pathway IMP
GO:0060338 regulation of type I interferon-mediated signaling pathway IMP
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0060334 regulation of interferon-gamma-mediated signaling pathway IMP
GO:0060338 regulation of type I interferon-mediated signaling pathway IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0060334 regulation of interferon-gamma-mediated signaling pathway IMP
GO:0060338 regulation of type I interferon-mediated signaling pathway IMP
GO:1901389 negative regulation of transforming growth factor beta activation IDA
click arrow to show/hide IEA associations
GO:0071353 cellular response to interleukin-4 IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0031396 regulation of protein ubiquitination IDA
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0043312 neutrophil degranulation TAS

References

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1. Gavenonis J, Jonas NE, Kritzer JA. (2014) Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix. Bioorg. Med. Chem., 22 (15): 3989-93. [PMID:24984936]

How to cite this page

Heat shock proteins: heat shock protein 90 alpha family class B member 1. Last modified on 04/03/2018. Accessed on 20/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2907.