heat shock protein 90 alpha family class B member 1

Target id: 2907

Nomenclature: heat shock protein 90 alpha family class B member 1

Abbreviated Name: HSP90AB1

Family: Heat shock proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     heat shock protein 90 alpha family class B member 1 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 724 6p21.1 HSP90AB1 heat shock protein 90 alpha family class B member 1
Mouse - 724 Chromosome 17, 22.59 cM Hsp90ab1 heat shock protein 90 alpha (cytosolic)
Rat - 724 9q12 Hsp90ab1 heat shock protein 90 alpha family class B member 1
Previous and Unofficial Names
HSP90AB1 | HSp90AB1 | heat shock protein 90 alpha (cytosolic), class B member 1
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
luminespib Hs Inhibition 8.7 pIC50
pIC50 8.7 (IC50 2x10-9 M)
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096) TAS
neutrophil degranulation (GO:0043312) TAS
regulation of interferon-gamma-mediated signaling pathway (GO:0060334) IMP
regulation of type I interferon-mediated signaling pathway (GO:0060338) IMP
References: 
Immuno Process:  Antigen presentation
Immuno Process ID:  3
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096) TAS
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096) TAS
regulation of interferon-gamma-mediated signaling pathway (GO:0060334) IMP
regulation of type I interferon-mediated signaling pathway (GO:0060338) IMP
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  regulation of interferon-gamma-mediated signaling pathway (GO:0060334) IMP
regulation of type I interferon-mediated signaling pathway (GO:0060338) IMP
cellular response to interleukin-4 (GO:0071353) IEA
negative regulation of transforming growth factor beta activation (GO:1901389) IDA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  regulation of protein ubiquitination (GO:0031396) IDA
Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096) TAS
neutrophil degranulation (GO:0043312) TAS
References: 

How to cite this page

Heat shock proteins: heat shock protein 90 alpha family class B member 1. Last modified on 08/05/2017. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2907.