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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 491 | 6q25.1 | KATNA1 | katanin catalytic subunit A1 | |
| Mouse | - | 491 | 10 A1 | Katna1 | katanin p60 (ATPase-containing) subunit A1 | |
| Rat | - | 491 | 1p13 | Katna1 | katanin catalytic subunit A1 | |
| Previous and Unofficial Names |
| katanin p60 (ATPase containing) subunit A 1 | microtubule-severing protein |
| Database Links |
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| Alphafold | O75449 (Hs), Q9WV86 (Mm), Q6E0V2 (Rn) |
| BRENDA | 3.6.4.3 |
| ChEMBL Target | CHEMBL3879856 (Hs) |
| Ensembl Gene | ENSG00000186625 (Hs), ENSMUSG00000019794 (Mm), ENSRNOG00000014996 (Rn) |
| Entrez Gene | 11104 (Hs), 23924 (Mm), 292464 (Rn) |
| Human Protein Atlas | ENSG00000186625 (Hs) |
| KEGG Enzyme | 3.6.4.3 |
| KEGG Gene | hsa:11104 (Hs), mmu:23924 (Mm), rno:292464 (Rn) |
| Pharos | O75449 (Hs) |
| RefSeq Nucleotide | NM_007044 (Hs), NM_011835 (Mm), NM_001004217 (Rn) |
| RefSeq Protein | NP_008975 (Hs), NP_035965 (Mm), NP_001004217 (Rn) |
| UniProtKB | O75449 (Hs), Q9WV86 (Mm), Q6E0V2 (Rn) |
| Wikipedia | KATNA1 (Hs) |
| Enzyme Reaction |
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| Immuno Process Associations | ||
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| General Comments |
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Katanin is a hydrolase enzyme composed of an ATP-dependent p60 catalytic subunit (KATNA1) and a p80 regulatory subunit (KATNB1) which targets the enzyme to the centrosome [1]. Katanin is required during meiosis and mitosis, being involved in dissasembling microtubules from their interphase structures and segregating chromatids towards the spindle pole during cell division [3]. Novel anti-cancer agents which induce microtubule fragmentation via interaction with katanin are being investigated [2]- see compound 5a [PMID: 27536893] for example. |
1. Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ. (1998) Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Cell, 93 (2): 277-87. [PMID:9568719]
2. Kuo TC, Li LW, Pan SH, Fang JM, Liu JH, Cheng TJ, Wang CJ, Hung PF, Chen HY, Hong TM et al.. (2016) Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin. J Med Chem, 59 (18): 8521-34. [PMID:27536893]
3. McNally FJ, Thomas S. (1998) Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs. Mol Biol Cell, 9 (7): 1847-61. [PMID:9658175]
AAA ATPases: katanin catalytic subunit A1. Last modified on 08/04/2021. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2912.
