katanin catalytic subunit A1

Target id: 2912

Nomenclature: katanin catalytic subunit A1

Family: AAA ATPases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for katanin catalytic subunit A1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 491 6q24.3 KATNA1 katanin catalytic subunit A1
Mouse - 493 10 A1 Katna1 katanin p60 (ATPase-containing) subunit A1
Rat - 493 1p13 Katna1 katanin catalytic subunit A1
Previous and Unofficial Names
katanin p60 (ATPase containing) subunit A 1 | microtubule-severing protein
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.6.4.3 ATP + H(2)O <=> ADP + phosphate
Description Reaction Reference
ATP + H(2)O <=> ADP + phosphate
General Comments
Katanin is a hydrolase enzyme composed of an ATP-dependent p60 catalytic subunit (KATNA1) and a p80 regulatory subunit (KATNB1) which targets the enzyme to the centrosome [1]. Katanin is required during meiosis and mitosis, being involved in dissasembling microtubules from their interphase structures and segregating chromatids towards the spindle pole during cell division [3].
Novel anti-cancer agents which induce microtubule fragmentation via interaction with katanin are being investigated [2]- see compound 5a [PMID: 27536893] for example.

References

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1. Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ. (1998) Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Cell93 (2): 277-87. [PMID:9568719]

2. Kuo TC, Li LW, Pan SH, Fang JM, Liu JH, Cheng TJ, Wang CJ, Hung PF, Chen HY, Hong TM et al.. (2016) Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin. J. Med. Chem.,  [Epub ahead of print]. [PMID:27536893]

3. McNally FJ, Thomas S. (1998) Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs. Mol. Biol. Cell9 (7): 1847-61. [PMID:9658175]

How to cite this page

AAA ATPases: katanin catalytic subunit A1. Last modified on 14/09/2016. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2912.