CD6

Target id: 2917

Nomenclature: CD6

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     CD6 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 668 11q12.2 CD6 CD6 molecule
Mouse 1 665 19, 7.16 cM Cd6 CD6 antigen
Rat - 665 1q43 Cd6 Cd6 molecule
Gene and Protein Information Comments
Details of alternate transcripts and protein isoforms identified for human and mouse CD6 are available from their NCBI (Entrez) gene entries.
Previous and Unofficial Names
Tp120
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
itolizumab Hs Binding 7.2 pKi 1
pKi 7.2 (Ki 6x10-8 M) [1]
Immunopharmacology Comments
CD6 is a co-stimulatory molecule, predominantly expressed on lymphocytes and associated with autoimmune responses. CD6 interacts with activated leucocyte-cell adhesion molecule (ALCAM/CD166), found on antigen presenting cells. This interaction induces the production of proinflammatory cytokines [2], prostaglandins, leukotrienes and oxygen free radicals.
Druggability is indicated by approval of the anti-CD6 monoclonal antibody itolizumab to treat psoriasis.
Cell Type Associations
Immuno Cell Type:  B cells
Immuno Cell Type:  T cells
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002438 acute inflammatory response to antigenic stimulus IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0042102 positive regulation of T cell proliferation IMP
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GO:0002250 adaptive immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0042102 positive regulation of T cell proliferation IMP
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0042102 positive regulation of T cell proliferation IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0001771 immunological synapse formation IMP
GO:0042102 positive regulation of T cell proliferation IMP
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0005044 scavenger receptor activity IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
Immuno Disease Associations
Disease Name:  Psoriasis
Disease Synonyms:  no synonynms
Comment:  CD6 is the molecular target of itolizumab, a drug approved for the treatment of chronic plaque psoriasis.
Disease X-refs:  Disease Ontology: DOID:8893
References: 

References

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1. Alonso R, Huerta V, de Leon J, Piedra P, Puchades Y, Guirola O, Chinea G, Montero E. (2008) Towards the definition of a chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody. Hybridoma (Larchmt), 27 (4): 291-301. [PMID:18707547]

2. Nair P, Melarkode R, Rajkumar D, Montero E. (2010) CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction. Clin. Exp. Immunol., 162 (1): 116-30. [PMID:20726988]

How to cite this page

CD molecules: CD6. Last modified on 06/02/2017. Accessed on 19/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2917.