CD6

Target id: 2917

Nomenclature: CD6

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     CD6 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 668 11q12.2 CD6 CD6 molecule
Mouse 1 665 19, 7.16 cM Cd6 CD6 antigen
Rat - 665 1q43 Cd6 Cd6 molecule
Gene and Protein Information Comments
Details of alternate transcripts and protein isoforms identified for human and mouse CD6 are available from their NCBI (Entrez) gene entries.
Previous and Unofficial Names
Tp120
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
itolizumab Hs Binding 7.2 pKi 1
pKi 7.2 (Ki 6x10-8 M) [1]
Immunopharmacology Comments
CD6 is a co-stimulatory molecule, predominantly expressed on lymphocytes and associated with autoimmune responses. CD6 interacts with activated leucocyte-cell adhesion molecule (ALCAM/CD166), found on antigen presenting cells. This interaction induces the production of proinflammatory cytokines [2], prostaglandins, leukotrienes and oxygen free radicals.
Druggability is indicated by approval of the anti-CD6 monoclonal antibody itolizumab to treat psoriasis.
Immuno Cell Type Associations
Immuno Cell Type:  B cells
Cell Ontology Term:  
Comment: 
References: 
Immuno Cell Type:  T cells
Cell Ontology Term:  
Comment: 
References: 
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  acute inflammatory response to antigenic stimulus (GO:0002438) IDA
innate immune response (GO:0045087) IEA
positive regulation of cytokine production involved in inflammatory response (GO:1900017) IDA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  adaptive immune response (GO:0002250) IEA
positive regulation of T cell proliferation (GO:0042102) IMP
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell proliferation (GO:0042102) IMP
positive regulation of cytokine production involved in inflammatory response (GO:1900017) IDA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of cytokine production involved in inflammatory response (GO:1900017) IDA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell proliferation (GO:0042102) IMP
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  immunological synapse formation (GO:0001771) IMP
positive regulation of T cell proliferation (GO:0042102) IMP
References: 
Immuno Process:  Antigen presentation
Immuno Process ID:  3
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  scavenger receptor activity (GO:0005044) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  adaptive immune response (GO:0002250) IEA
References: 
Immuno Disease Associations
Disease Name:  Psoriasis
Disease Synonyms:  no synonynms
Comment:  CD6 is the molecular target of itolizumab, a drug approved for the treatment of chronic plaque psoriasis.
Disease X-refs:  Disease Ontology: DOID:8893
References: 

References

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1. Alonso R, Huerta V, de Leon J, Piedra P, Puchades Y, Guirola O, Chinea G, Montero E. (2008) Towards the definition of a chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody. Hybridoma (Larchmt)27 (4): 291-301. [PMID:18707547]

2. Nair P, Melarkode R, Rajkumar D, Montero E. (2010) CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction. Clin. Exp. Immunol.162 (1): 116-30. [PMID:20726988]

How to cite this page

CD molecules: CD6. Last modified on 06/02/2017. Accessed on 12/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2917.