DExD/H-box helicase 58

Target id: 2920

Nomenclature: DExD/H-box helicase 58

Abbreviated Name: RIG-1

Family: RIG-I-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     DExD/H-box helicase 58 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 925 9p21.1 DDX58 DExD/H-box helicase 58
Mouse - 926 4 A5 Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Rat - 598 5q22 Ddx58 DEXD/H-box helicase 58
Previous and Unofficial Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | retinoic acid inducible gene I | RNA helicase RIG-I
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.6.4.13
Description Reaction Reference
RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate
Immunopharmacology Comments
RIG-I is an intracellular sensor that responds to viral nucleic acids and activates downstream signaling, resulting in the induction of the type I interferon response [1]. RIG-I recognizes RNAs from more that 25 viruses and can detect dsRNAs, ssRNAs harboring a 5′-triphosphate and blunt-ended 5′-triphosphate-containing dsRNAs. Dysregulated RIG-I signaling has been associated with autoimmune disorders [1].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus TAS
GO:0039529 RIG-I signaling pathway IMP
GO:0045087 innate immune response IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0002230 positive regulation of defense response to virus by host IMP
GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus TAS
GO:0039529 RIG-I signaling pathway IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 14 GO processes
GO:0032480 negative regulation of type I interferon production TAS
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IDA
GO:0032727 positive regulation of interferon-alpha production IDA
GO:0032728 positive regulation of interferon-beta production IDA
GO:0032755 positive regulation of interleukin-6 production IDA
GO:0032757 positive regulation of interleukin-8 production IDA
GO:0034344 regulation of type III interferon production TAS
GO:0035549 positive regulation of interferon-beta secretion IMP
GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus TAS
GO:0039529 RIG-I signaling pathway IMP
GO:0060760 positive regulation of response to cytokine stimulus IMP
GO:1902741 positive regulation of interferon-alpha secretion IMP
GO:1904469 positive regulation of tumor necrosis factor secretion IMP
GO:2000778 positive regulation of interleukin-6 secretion IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus TAS
GO:0039529 RIG-I signaling pathway IMP
Physiological Consequences of Altering Gene Expression
Conventional dendritic cells (cDCs), macrophages and fibroblasts isolated from RIG-1 null mice have impaired IFN induction after RNA virus infection. Plasmacytoid DCs are unaffected by RIG-1 knockout, suggesting nucleic acid sensing TLRs are more relevant in these cells.
Species:  Mouse
Tissue:  cDCs, macrophages and fibroblasts,
Technique: 
References: 

References

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1. Matsumiya T, Stafforini DM. (2010) Function and regulation of retinoic acid-inducible gene-I. Crit. Rev. Immunol., 30 (6): 489-513. [PMID:21175414]

How to cite this page

RIG-I-like receptor family: DExD/H-box helicase 58. Last modified on 07/02/2018. Accessed on 19/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2920.