interferon induced with helicase C domain 1

Target id: 2921

Nomenclature: interferon induced with helicase C domain 1

Abbreviated Name: MDA5

Family: RIG-I-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     interferon induced with helicase C domain 1 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1025 2q24.2 IFIH1 interferon induced with helicase C domain 1
Mouse - 976 2 C1.3 Ifih1 interferon induced with helicase C domain 1
Rat - 1027 3q21 Ifih1 interferon induced with helicase C domain 1
Previous and Unofficial Names
melanoma differentiation-associated gene 5 | MDA-5
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.6.4.13
Description Reaction Reference
RNA helicase; uses the energy from ATP to unwind RNA ATP + H(2)O <=> ADP + phosphate
Immunopharmacology Comments
MDA5 is an intracellualar RNA sensor. It recognizes longer double-stranded RNA sequences than RIG-1. In autoimmunity, MDA5 has been specifically linked with type I diabetes and anti-MDA5 autoantibodies can be detected in patients with certain connective tissue autoimmune conditions [1-3].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus TAS
GO:0039530 MDA-5 signaling pathway IDA
GO:0045087 innate immune response TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus TAS
GO:0039530 MDA-5 signaling pathway IDA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 11 GO processes
GO:0032480 negative regulation of type I interferon production TAS
GO:0032727 positive regulation of interferon-alpha production IMP
GO:0032728 positive regulation of interferon-beta production IDA
GO:0034344 regulation of type III interferon production TAS
GO:0035549 positive regulation of interferon-beta secretion IMP
GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus TAS
GO:0039530 MDA-5 signaling pathway IDA
GO:0060760 positive regulation of response to cytokine stimulus IMP
GO:1902741 positive regulation of interferon-alpha secretion IMP
GO:1904469 positive regulation of tumor necrosis factor secretion IMP
GO:2000778 positive regulation of interleukin-6 secretion IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus TAS
GO:0039530 MDA-5 signaling pathway IDA
Physiological Consequences of Altering Gene Expression
Conventional dendritic cells (cDCs), macrophages and fibroblasts isolated from MDA5 null mice have impaired IFN induction after RNA virus infection. Plasmacytoid DCs are unaffected by MDA5 knockout, suggesting nucleic acid sensing TLRs are more relevant in these cells.
Species:  Mouse
Tissue:  cDCs, macrophages and fibroblasts.
Technique: 
References: 

References

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1. Ahlers LR, Goodman AG. (2016) Nucleic acid sensing and innate immunity: signaling pathways controlling viral pathogenesis and autoimmunity. Curr Clin Microbiol Rep, 3 (3): 132-141. [PMID:27857881]

2. Hozumi H, Fujisawa T, Nakashima R, Johkoh T, Sumikawa H, Murakami A, Enomoto N, Inui N, Nakamura Y, Hosono Y et al.. (2016) Comprehensive assessment of myositis-specific autoantibodies in polymyositis/dermatomyositis-associated interstitial lung disease. Respir Med, 121: 91-99. [PMID:27888997]

3. Milam EC, Futran J, Franks Jr AG. (2016) Anti-MDA5 Antibody Dermatomyositis Overlap with Systemic Lupus Erythematosus: A Case Report and Review of the Literature. Open Rheumatol J, 10: 122-128. [PMID:28077979]

How to cite this page

RIG-I-like receptor family: interferon induced with helicase C domain 1. Last modified on 07/02/2018. Accessed on 17/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2921.