interferon induced with helicase C domain 1

Target id: 2921

Nomenclature: interferon induced with helicase C domain 1

Abbreviated Name: MDA5

Family: RIG-I-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     interferon induced with helicase C domain 1 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1025 2q24.2 IFIH1 interferon induced with helicase C domain 1
Mouse - 976 2 C1.3 Ifih1 interferon induced with helicase C domain 1
Rat - 1027 3q21 Ifih1 interferon induced with helicase C domain 1
Previous and Unofficial Names
melanoma differentiation-associated gene 5 | MDA-5
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.6.4.13
Description Reaction Reference
RNA helicase; uses the energy from ATP to unwind RNA ATP + H(2)O <=> ADP + phosphate
Immunopharmacology Comments
MDA5 is an intracellualar RNA sensor. It recognizes longer double-stranded RNA sequences than RIG-1. In autoimmunity, MDA5 has been specifically linked with type I diabetes and anti-MDA5 autoantibodies can be detected in patients with certain connective tissue autoimmune conditions [1-3].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  cytoplasmic pattern recognition receptor signaling pathway in response to virus (GO:0039528) TAS
MDA-5 signaling pathway (GO:0039530) IDA
innate immune response (GO:0045087) TAS
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  cytoplasmic pattern recognition receptor signaling pathway in response to virus (GO:0039528) TAS
MDA-5 signaling pathway (GO:0039530) IDA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  negative regulation of type I interferon production (GO:0032480) TAS
positive regulation of interferon-alpha production (GO:0032727) IMP
positive regulation of interferon-beta production (GO:0032728) IDA
regulation of type III interferon production (GO:0034344) TAS
cytoplasmic pattern recognition receptor signaling pathway in response to virus (GO:0039528) TAS
MDA-5 signaling pathway (GO:0039530) IDA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  cytoplasmic pattern recognition receptor signaling pathway in response to virus (GO:0039528) TAS
MDA-5 signaling pathway (GO:0039530) IDA
References: 
Physiological Consequences of Altering Gene Expression
Conventional dendritic cells (cDCs), macrophages and fibroblasts isolated from MDA5 null mice have impaired IFN induction after RNA virus infection. Plasmacytoid DCs are unaffected by MDA5 knockout, suggesting nucleic acid sensing TLRs are more relevant in these cells.
Species:  Mouse
Tissue:  cDCs, macrophages and fibroblasts.
Technique: 
References: 

References

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1. Ahlers LR, Goodman AG. (2016) Nucleic acid sensing and innate immunity: signaling pathways controlling viral pathogenesis and autoimmunity. Curr Clin Microbiol Rep3 (3): 132-141. [PMID:27857881]

2. Hozumi H, Fujisawa T, Nakashima R, Johkoh T, Sumikawa H, Murakami A, Enomoto N, Inui N, Nakamura Y, Hosono Y et al.. (2016) Comprehensive assessment of myositis-specific autoantibodies in polymyositis/dermatomyositis-associated interstitial lung disease. Respir Med121: 91-99. [PMID:27888997]

3. Milam EC, Futran J, Franks Jr AG. (2016) Anti-MDA5 Antibody Dermatomyositis Overlap with Systemic Lupus Erythematosus: A Case Report and Review of the Literature. Open Rheumatol J10: 122-128. [PMID:28077979]

How to cite this page

RIG-I-like receptor family: interferon induced with helicase C domain 1. Last modified on 20/03/2017. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2921.