DExH-box helicase 58

Target id: 2922

Nomenclature: DExH-box helicase 58

Abbreviated Name: LGP2

Family: RIG-I-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     DExH-box helicase 58 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 678 17q21.2 DHX58 DExH-box helicase 58
Mouse - 678 11 D; 11 63.52 cM Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58
Rat - 678 10q31 Dhx58 DEXH-box helicase 58
Previous and Unofficial Names
DEXH (Asp-Glu-X-His) box polypeptide 58 | RNA helicase LGP2
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.6.4.13
Description Reaction Reference
RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate
Immunopharmacology Comments
LGP2 binds RNA but does not participate in the signaling pathway that RIG-1 and MDA5 are part of, and is assumed to provide a negative feedback for IFNβ induction by sequestering pathogen-derived RNA.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  negative regulation of MDA-5 signaling pathway (GO:0039534) IMP
negative regulation of RIG-I signaling pathway (GO:0039536) IDA
innate immune response (GO:0045087) IEA
regulation of innate immune response (GO:0045088) IDA
negative regulation of innate immune response (GO:0045824) IDA
positive regulation of MDA-5 signaling pathway (GO:1900245) ISS
positive regulation of RIG-I signaling pathway (GO:1900246) ISS
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  negative regulation of MDA-5 signaling pathway (GO:0039534) IMP
negative regulation of RIG-I signaling pathway (GO:0039536) IDA
regulation of innate immune response (GO:0045088) IDA
negative regulation of innate immune response (GO:0045824) IDA
positive regulation of MDA-5 signaling pathway (GO:1900245) ISS
positive regulation of RIG-I signaling pathway (GO:1900246) ISS
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  negative regulation of type I interferon production (GO:0032480) IDA
positive regulation of type I interferon production (GO:0032481) ISS
negative regulation of MDA-5 signaling pathway (GO:0039534) IMP
negative regulation of RIG-I signaling pathway (GO:0039536) IDA
positive regulation of MDA-5 signaling pathway (GO:1900245) ISS
positive regulation of RIG-I signaling pathway (GO:1900246) ISS
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  negative regulation of MDA-5 signaling pathway (GO:0039534) IMP
negative regulation of RIG-I signaling pathway (GO:0039536) IDA
positive regulation of MDA-5 signaling pathway (GO:1900245) ISS
positive regulation of RIG-I signaling pathway (GO:1900246) ISS
References: 

How to cite this page

RIG-I-like receptor family: DExH-box helicase 58. Last modified on 20/03/2017. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2922.