DExH-box helicase 58

Target id: 2922

Nomenclature: DExH-box helicase 58

Abbreviated Name: LGP2

Family: RIG-I-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     DExH-box helicase 58 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 678 17q21.2 DHX58 DExH-box helicase 58
Mouse - 678 11 D; 11 63.52 cM Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58
Rat - 678 10q31 Dhx58 DEXH-box helicase 58
Previous and Unofficial Names
DEXH (Asp-Glu-X-His) box polypeptide 58 | RNA helicase LGP2
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.6.4.13
Description Reaction Reference
RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate
Immunopharmacology Comments
LGP2 binds RNA but does not participate in the signaling pathway that RIG-1 and MDA5 are part of, and is assumed to provide a negative feedback for IFNβ induction by sequestering pathogen-derived RNA.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 7 GO processes
GO:0039534 negative regulation of MDA-5 signaling pathway IMP
GO:0039536 negative regulation of RIG-I signaling pathway IDA
GO:0045088 regulation of innate immune response IDA
GO:0045824 negative regulation of innate immune response IDA
GO:1900245 positive regulation of MDA-5 signaling pathway ISS
GO:1900246 positive regulation of RIG-I signaling pathway ISS
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 6 GO processes
GO:0039534 negative regulation of MDA-5 signaling pathway IMP
GO:0039536 negative regulation of RIG-I signaling pathway IDA
GO:0045088 regulation of innate immune response IDA
GO:0045824 negative regulation of innate immune response IDA
GO:1900245 positive regulation of MDA-5 signaling pathway ISS
GO:1900246 positive regulation of RIG-I signaling pathway ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 6 GO processes
GO:0032480 negative regulation of type I interferon production IDA
GO:0032481 positive regulation of type I interferon production ISS
GO:0039534 negative regulation of MDA-5 signaling pathway IMP
GO:0039536 negative regulation of RIG-I signaling pathway IDA
GO:1900245 positive regulation of MDA-5 signaling pathway ISS
GO:1900246 positive regulation of RIG-I signaling pathway ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0039534 negative regulation of MDA-5 signaling pathway IMP
GO:0039536 negative regulation of RIG-I signaling pathway IDA
GO:1900245 positive regulation of MDA-5 signaling pathway ISS
GO:1900246 positive regulation of RIG-I signaling pathway ISS

How to cite this page

RIG-I-like receptor family: DExH-box helicase 58. Last modified on 07/02/2018. Accessed on 18/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2922.