absent in melanoma 2

Target id: 2923

Nomenclature: absent in melanoma 2

Abbreviated Name: AIM2

Family: Absent in melanoma (AIM)-like receptors (ALRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     absent in melanoma 2 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 343 1q23.1-q23.2 AIM2 absent in melanoma 2
Mouse - 354 C1, 80.33 cM Aim2 absent in melanoma 2
Rat - 356 13q24 Aim2 absent in melanoma 2
Gene and Protein Information Comments
The human gene has a second reported splice variant generating a shorter protein isofom, with a shorter N-terminus (238 amino acids).
Previous and Unofficial Names
interferon-inducible protein AIM2 | PYHIN4
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
AIM2 primarily senses cytosolic DNA and initiates formation of an inflammasome to drive IL-1β cleavage and secretion.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002218 activation of innate immune response IDA
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GO:0006954 inflammatory response IEA
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0002218 activation of innate immune response IDA
GO:0002230 positive regulation of defense response to virus by host ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 5 GO processes
GO:0032731 positive regulation of interleukin-1 beta production IDA
GO:0033209 tumor necrosis factor-mediated signaling pathway IDA
GO:0050702 interleukin-1 beta secretion IMP
GO:0050718 positive regulation of interleukin-1 beta secretion IDA
click arrow to show/hide IEA associations
GO:0035458 cellular response to interferon-beta IEA
General Comments
AIM2 is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995) [1].

References

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1. Schattgen SA, Fitzgerald KA. (2011) The PYHIN protein family as mediators of host defenses. Immunol. Rev.243 (1): 109-18. [PMID:21884171]

How to cite this page

Absent in melanoma (AIM)-like receptors (ALRs): absent in melanoma 2. Last modified on 03/03/2017. Accessed on 20/04/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2923.