absent in melanoma 2

Target id: 2923

Nomenclature: absent in melanoma 2

Abbreviated Name: AIM2

Family: Absent in melanoma (AIM)-like receptors (ALRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     absent in melanoma 2 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 343 1q23.1-q23.2 AIM2 absent in melanoma 2
Mouse - 354 C1, 80.33 cM Aim2 absent in melanoma 2
Rat - 356 13q24 Aim2 absent in melanoma 2
Gene and Protein Information Comments
The human gene has a second reported splice variant generating a shorter protein isofom, with a shorter N-terminus (238 amino acids).
Previous and Unofficial Names
interferon-inducible protein AIM2 | PYHIN4
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
AIM2 primarily senses cytosolic DNA and initiates formation of an inflammasome to drive IL-1β cleavage and secretion.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  activation of innate immune response (GO:0002218) IDA
inflammatory response (GO:0006954) IEA
innate immune response (GO:0045087) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  activation of innate immune response (GO:0002218) IDA
positive regulation of defense response to virus by host (GO:0002230) ISS
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of interleukin-1 beta production (GO:0032731) IDA
tumor necrosis factor-mediated signaling pathway (GO:0033209) IDA
cellular response to interferon-beta (GO:0035458) IEA
interleukin-1 beta secretion (GO:0050702) IMP
positive regulation of interleukin-1 beta secretion (GO:0050718) IDA
References: 
General Comments
AIM2 is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995) [1].

References

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1. Schattgen SA, Fitzgerald KA. (2011) The PYHIN protein family as mediators of host defenses. Immunol. Rev.243 (1): 109-18. [PMID:21884171]

How to cite this page

Absent in melanoma (AIM)-like receptors (ALRs): absent in melanoma 2. Last modified on 03/03/2017. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2923.