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target has curated data in GtoImmuPdb
Target id: 2925
Nomenclature: pyrin and HIN domain family member 1
Abbreviated Name: PYHIN1
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 492 | 1q23.1 | PYHIN1 | pyrin and HIN domain family member 1 | |
| Gene and Protein Information Comments | ||||||
| Alternative transcription of the human gene gives rise to several protein isoforms: alpha 1 (presented here), alpha 2, beta a and beta 2. There are no mouse or rat homologs of human PYHIN1 with 1:1 orthology. | ||||||
| Previous and Unofficial Names |
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| IFIX i [2] | |
| Database Links |
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| Alphafold | Q6K0P9 (Hs) |
| Ensembl Gene | ENSG00000163564 (Hs) |
| Entrez Gene | 149628 (Hs) |
| Human Protein Atlas | ENSG00000163564 (Hs) |
| KEGG Gene | hsa:149628 (Hs) |
| OMIM | 612677 (Hs) |
| Pharos | Q6K0P9 (Hs) |
| RefSeq Nucleotide | NM_152501 (Hs) |
| RefSeq Protein | NP_689714 (Hs) |
| UniProtKB | Q6K0P9 (Hs) |
| Wikipedia | PYHIN1 (Hs) |
| Immunopharmacology Comments |
| PYHIN1 participates in the innate immune response to microbial DNA [1], and contributes to the induction of the interferon response to viral pathogens. |
| Immuno Process Associations | ||
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| General Comments |
| PYHIN1 is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995). In addition to acting as a sensor of viral DNA, PYHIN1 also interacts with factors involved in transcriptional regulation and chromatin modulation [1]. |
1. Diner BA, Li T, Greco TM, Crow MS, Fuesler JA, Wang J, Cristea IM. (2015) The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Mol Syst Biol, 11 (1): 787. [PMID:25665578]
2. Ding Y, Wang L, Su LK, Frey JA, Shao R, Hunt KK, Yan DH. (2004) Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer. Oncogene, 23 (26): 4556-66. [PMID:15122330]
Absent in melanoma (AIM)-like receptors (ALRs): pyrin and HIN domain family member 1. Last modified on 20/03/2017. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2925.
