myeloid cell nuclear differentiation antigen

Target id: 2926

Nomenclature: myeloid cell nuclear differentiation antigen

Abbreviated Name: MNDA

Family: Absent in melanoma (AIM)-like receptors (ALRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     myeloid cell nuclear differentiation antigen has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 407 1q23.1 MNDA myeloid cell nuclear differentiation antigen
Rat - 438 13q24 Mnda myeloid cell nuclear differentiation antigen
Gene and Protein Information Comments
There are no mouse homologs of human MNDA.
Previous and Unofficial Names
PYHIN3
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Agonist Comments
The HIN (ligand binding) domain of MDNA binds double-stranded DNA with a Kd of 3.15 μM [2].
Immunopharmacology Comments
MNDA can be detected exclusively in nuclei of hematopoietic cells of the monocyte lineage. Expression is induced by interferon α [1]. The HIN domain of MNDA binds double-stranded DNA [2], and produces an innate resonse against pathogens. MNDA may be able to detect some viruses not recognized by AIM2.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  neutrophil degranulation (GO:0043312) TAS
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  negative regulation of B cell proliferation (GO:0030889) IMP
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  negative regulation of B cell proliferation (GO:0030889) IMP
B cell receptor signaling pathway (GO:0050853) IMP
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  negative regulation of B cell proliferation (GO:0030889) IMP
neutrophil degranulation (GO:0043312) TAS
B cell receptor signaling pathway (GO:0050853) IMP
References: 
General Comments
MNDA is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995).

References

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1. Briggs JA, Burrus GR, Stickney BD, Briggs RC. (1992) Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. J. Cell. Biochem.49 (1): 82-92. [PMID:1644857]

2. Li H, Wang ZX, Wu JW. (2014) Purification, characterization and docking studies of the HIN domain of human myeloid nuclear differentiation antigen (MNDA). Biotechnol. Lett.36 (5): 899-905. [PMID:24557068]

How to cite this page

Absent in melanoma (AIM)-like receptors (ALRs): myeloid cell nuclear differentiation antigen. Last modified on 03/03/2017. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2926.