C-type lectin domain family 7 member A

Target id: 2927

Nomenclature: C-type lectin domain family 7 member A

Abbreviated Name: Dectin-1

Family: C-type lectin-like receptors (CLRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     C-type lectin domain family 7 member A has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 247 12p13.2 CLEC7A C-type lectin domain containing 7A
Mouse 1 244 C6, 63.34 cM, cytoband F3 Clec7a C-type lectin domain family 7, member a
Rat 1 235 Clec7a C-type lectin domain containing 7A
Gene and Protein Information Comments
There are six recognised variants of human CLEC7A (a-f), encoding protein isoforms of different lengths. We present variant a/isoform 1 here as the longest transcript and protein. A shorter isoform of the mouse gene with 199 amino acids has been identified.
Previous and Unofficial Names
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 | CLECSF12 | CD369 | SCARE2 | Beta-glucan receptor BGR | Dendritic cell-associated C-type lectin 1 | C-type lectin domain family 7, member A
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Agonist Comments
A series of Dectin-1 agonist β(1,3) oligosaccharides with aminoalkyl groups are reported in [2].
Immunopharmacology Comments
Dectin-1 is a pattern recognition receptor involved in initiating the innate immune response upon recognition of various β(1,3)-linked and β(1,6)-linked glucans from fungi and plants. It mediates phagocytosis and the production of inflammatory mediators [1].
Immuno Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:  
Comment:  Dectin-1 is widely expressed in macrophage populations.
References:  1
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  stimulatory C-type lectin receptor signaling pathway (GO:0002223) TAS
phagocytosis, recognition (GO:0006910) IDA
inflammatory response (GO:0006954) IEA
signaling pattern recognition receptor activity (GO:0008329) IDA
innate immune response (GO:0045087) IEA
References: 
Immuno Process:  Antigen presentation
Immuno Process ID:  3
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  phagocytosis, recognition (GO:0006910) IDA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  T cell activation (GO:0042110) TAS
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  stimulatory C-type lectin receptor signaling pathway (GO:0002223) TAS
signaling pattern recognition receptor activity (GO:0008329) IDA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  stimulatory C-type lectin receptor signaling pathway (GO:0002223) TAS
signaling pattern recognition receptor activity (GO:0008329) IDA
T cell activation (GO:0042110) TAS
References: 
General Comments
Dectin-1 is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).

References

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1. Brown GD, Gordon S. (2001) Immune recognition: A new receptor for β-glucans. Nature413: 36-37 Brief Communications.

2. Tanaka H, Kawai T, Adachi Y, Hanashima S, Yamaguchi Y, Ohno N, Takahashi T. (2012) Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation. Bioorg. Med. Chem.20 (12): 3898-914. [PMID:22578491]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 7 member A. Last modified on 02/03/2017. Accessed on 21/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2927.