C-type lectin domain family 6 member A

Target id: 2928

Nomenclature: C-type lectin domain family 6 member A

Abbreviated Name: Dectin-2

Family: C-type lectin-like receptors (CLRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     C-type lectin domain family 6 member A has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 209 12p13.31 CLEC6A C-type lectin domain containing 6A
Mouse 1 209 C6, 58.30 cM, cytoband F3 Clec4n C-type lectin domain family 4, member n
Gene and Protein Information Comments
A shorter transcript and protein isoform of human the CLEC6A gene have been reported [1]. Two alternative transcripts and protein isoforms arising from the mouse gene have been identified. A rat homolog of human CLEC6A has not been identified.
Previous and Unofficial Names
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10 | CLECSF10 | CLEC4N | C-type lectin domain family 4, member n | C-type lectin domain family 4
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
Dectin-2 is involved in initiating the innate immune response upon recognition of high mannose structures on fungal cell walls. It associates with the ITAM-containing FcRβ adaptor and signals through the Syk, PKCδ, and CARD9-Bcl10-MALT1 pathways to promote cytokine production in response to fungal infection.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0045087 innate immune response ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0050715 positive regulation of cytokine secretion ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002250 adaptive immune response IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
General Comments
Dectin-2 is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).

References

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1. Gavino AC, Chung JS, Sato K, Ariizumi K, Cruz Jr PD. (2005) Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2. Exp. Dermatol., 14 (4): 281-8. [PMID:15810886]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 6 member A. Last modified on 20/03/2017. Accessed on 21/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2928.