C-type lectin domain family 4 member E

Target id: 2929

Nomenclature: C-type lectin domain family 4 member E

Abbreviated Name: Mincle

Family: C-type lectin-like receptors (CLRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     C-type lectin domain family 4 member E has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 219 12p13.31 CLEC4E C-type lectin domain family 4 member E
Mouse 1 214 C6, 58.35 cM, cytoband F3 Clec4e C-type lectin domain family 4, member e
Rat 1 2150 4q42 Clec4e C-type lectin domain family 4, member E
Previous and Unofficial Names
CLECSF9 | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 | Macrophage-inducible C-type lectin
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
GlcC14C18 Hs Agonist ~10.0 pEC50 2
pEC50 ~10.0 (EC50 ~1x10-10 M) [2]
Description: Measuring activation of an NF-κB reporter in HEK293 cells expressing human mincle.
Immunopharmacology Comments
Mincle is an FcRγ-associated membrane receptor involved in initiating the innate immune response upon recognition of endogenous and exogenous ligands including Sin3A-associated protein (SAP130), α-mannan on fungal cell walls and mycobacterial cord factor (trehalose-6,6′-dimycolate (TDM)) [1]. Mincle signals to NF-κB via the Syk-Card9-Bcl10-Malt1 pathway and induces a robust Th1 and Th17 response. Mincle is being targeted pharmacologically in an attempt to produce novel vaccine adjuvants that enhance cell-mediated immune responses [2]- in this case based on the immunogenicity of TDM.
Mincle's role in human B cell responses was investigated in [3].
Immuno Cell Type Associations
Immuno Cell Type:  B cells
Cell Ontology Term:   B cell (CL:0000236)
Comment: 
References:  3
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   neutrophil (CL:0000775)
Comment: 
References:  3
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
Comment: 
References: 
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   macrophage (CL:0000235)
Comment: 
References: 
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  stimulatory C-type lectin receptor signaling pathway (GO:0002223) TAS
T cell differentiation involved in immune response (GO:0002292) IEA
innate immune response (GO:0045087) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  stimulatory C-type lectin receptor signaling pathway (GO:0002223) TAS
Fc-gamma receptor signaling pathway (GO:0038094) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  stimulatory C-type lectin receptor signaling pathway (GO:0002223) TAS
T cell differentiation involved in immune response (GO:0002292) IEA
Fc-gamma receptor signaling pathway (GO:0038094) IEA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  T cell differentiation involved in immune response (GO:0002292) IEA
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  T cell differentiation involved in immune response (GO:0002292) IEA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of cytokine secretion (GO:0050715) IEA
References: 
General Comments
Mincle is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).

References

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1. Bryant CE, Orr S, Ferguson B, Symmons MF, Boyle JP, Monie TP. (2015) International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacol. Rev.67 (2): 462-504. [PMID:25829385]

2. Decout A, Silva-Gomes S, Drocourt D, Barbe S, André I, Cueto FJ, Lioux T, Sancho D, Pérouzel E, Vercellone A et al.. (2017) Rational design of adjuvants targeting the C-type lectin Mincle. Proc. Natl. Acad. Sci. U.S.A.,  [Epub ahead of print]. [PMID:28223515]

3. Kawata K, Illarionov P, Yang GX, Kenny TP, Zhang W, Tsuda M, Ando Y, Leung PS, Ansari AA, Eric Gershwin M. (2012) Mincle and human B cell function. J. Autoimmun.39 (4): 315-22. [PMID:22698596]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 4 member E. Last modified on 16/05/2017. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2929.