CD209 molecule

Target id: 2930

Nomenclature: CD209 molecule

Abbreviated Name: DC-SIGN

Family: C-type lectin-like receptors (CLRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     CD209 molecule has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 404 19p13.2 CD209 CD209 molecule
Gene and Protein Information Comments
A number of splice variants, encoding different protein isoforms of human CD209 have been identified. The mouse has five CD209 homologs and there are no rat homologs.
Previous and Unofficial Names
CLEC4L | CDSIGN
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
DC-SIGN is a pathogen-recognition receptor involved in initiating the primary immune response to various viral and bacterial pathogens, as well as antigen presentation and initiation of the adaptive immune response.
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
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GO:0045087 innate immune response IEA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 3 GO processes
GO:0019882 antigen processing and presentation NAS
GO:0046968 peptide antigen transport NAS
click arrow to show/hide IEA associations
GO:0006897 endocytosis IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 3 GO processes
GO:0042102 positive regulation of T cell proliferation IDA
GO:0042129 regulation of T cell proliferation IDA
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0042102 positive regulation of T cell proliferation IDA
GO:0042129 regulation of T cell proliferation IDA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 4 GO processes
GO:0007159 leukocyte cell-cell adhesion NAS
GO:0042102 positive regulation of T cell proliferation IDA
GO:0042129 regulation of T cell proliferation IDA
GO:0097323 B cell adhesion IDA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0042102 positive regulation of T cell proliferation IDA
GO:0042129 regulation of T cell proliferation IDA
Immuno Process:  Barrier integrity
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0001618 virus receptor activity IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
General Comments
DC-SIGN (CD209) is a pathogen-recognition receptor expressed on the surface of immature dendritic cells.

How to cite this page

C-type lectin-like receptors (CLRs): CD209 molecule. Last modified on 20/03/2017. Accessed on 22/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2930.