CD209 molecule

Target id: 2930

Nomenclature: CD209 molecule

Abbreviated Name: DC-SIGN

Family: C-type lectin-like receptors (CLRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     CD209 molecule has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 404 19p13.2 CD209 CD209 molecule
Gene and Protein Information Comments
A number of splice variants, encoding different protein isoforms of human CD209 have been identified. The mouse has five CD209 homologs and there are no rat homologs.
Previous and Unofficial Names
CLEC4L | CDSIGN
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
DC-SIGN is a pathogen-recognition receptor involved in initiating the primary immune response to various viral and bacterial pathogens, as well as antigen presentation and initiation of the adaptive immune response.
Immuno Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:  
Comment: 
References: 
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  stimulatory C-type lectin receptor signaling pathway (GO:0002223) TAS
innate immune response (GO:0045087) IEA
References: 
Immuno Process:  Antigen presentation
Immuno Process ID:  3
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  endocytosis (GO:0006897) IEA
antigen processing and presentation (GO:0019882) NAS
peptide antigen transport (GO:0046968) NAS
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  adaptive immune response (GO:0002250) IEA
positive regulation of T cell proliferation (GO:0042102) IDA
regulation of T cell proliferation (GO:0042129) IDA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  stimulatory C-type lectin receptor signaling pathway (GO:0002223) TAS
positive regulation of T cell proliferation (GO:0042102) IDA
regulation of T cell proliferation (GO:0042129) IDA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  leukocyte cell-cell adhesion (GO:0007159) NAS
positive regulation of T cell proliferation (GO:0042102) IDA
regulation of T cell proliferation (GO:0042129) IDA
B cell adhesion (GO:0097323) IDA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  stimulatory C-type lectin receptor signaling pathway (GO:0002223) TAS
positive regulation of T cell proliferation (GO:0042102) IDA
regulation of T cell proliferation (GO:0042129) IDA
References: 
Immuno Process:  Barrier integrity
Immuno Process ID:  1
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  virus receptor activity (GO:0001618) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  adaptive immune response (GO:0002250) IEA
References: 
General Comments
DC-SIGN (CD209) is a pathogen-recognition receptor expressed on the surface of immature dendritic cells.

How to cite this page

C-type lectin-like receptors (CLRs): CD209 molecule. Last modified on 20/03/2017. Accessed on 18/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2930.